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NCT Number: NCT06608147

MOLyF : Bone Marrow and Follicular Lymphoma

This is a prospective single-center study designed to assess potential differences in cell composition between bone marrows of patients with follicular lymphoma and those from control subjects.

Follicular lymphoma is the most common indolent lymphoma. It is characterised by systematic relapses and bone marrow dissemination in 70% of patients at the time of diagnosis.

Although relapses are thought to be related to refractory tumour cells nested in a supportive microenvironment in the bone marrow, the mechanisms involved are poorly understood.

To study the specificities of the bone marrow of patients with follicular lymphoma, It is necessary to compare them with control samples.

This study takes advantage of surgeries involving sternotomies to recover lost bone marrow and establish a bone marrow bank of patients without hematological disease.

This bank will be used to set up control cohorts for other clinical trials involving patients with follicular lymphoma.

Recruiting

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Key information

Conditions

Lymphoma, Follicular Hemic and Lymphatic Diseases Immune System Diseases Immunoproliferative Disorders Lymphatic Diseases Lymphoma Lymphoma, Non-Hodgkin Lymphoproliferative Disorders Neoplasms Neoplasms by Histologic Type

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

CHU Rennes

Rennes, 35009, France

Location status: Recruiting

Location contact

Juliette Ferrant, MD

CONTACT

[email protected]

0299282555 ext. +33

Juliette Ferrant, MD

PRINCIPAL_INVESTIGATOR

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Major patient
  • Patient hospitalized in the thoracic, cardiac and vascular surgery department for surgery involving a sternotomy
  • Patient with free, informed, written consent
  • Patient covered by a health insurance scheme

Exclusion criteria

  • History of haematological malignancy or haemogram disturbance
  • Immunomodulating treatment: immunosuppressants, corticoids, antineoplastics
  • Persons covered by articles L. 1121-5 to L. 1121-8 and L. 1122-1-2 of the French Public Health Code (e.g. minors, protected adults, etc.)].

Treatment and study plan

Sampling

Other

sternal bone marrow aspiration

Primary outcomes

  1. Flow cytometric quantification of cell populations

    Time frame: 1 day

    Bone marrow cell populations of lymphoma-free patients (lymphoid cells, myeloid cells, stromal cells and adventitial cells) will be quantified using a flow cytometry panel and compared with those of Follicular Lymphoma patients.

Study contacts

Contact information is provided by the study sponsor or research team.

Alexandra Guerrier

CONTACT

[email protected]

0299282555 ext. +33

Juliette Ferrant, MD

CONTACT

[email protected]

0299282555 ext. +33

Sponsors and collaborators

Lead sponsor

Rennes University Hospital

Other

Registry information

Official study title

Bone Marrow and Follicular Lymphoma

Acronym: MOLyF

Important dates

Study start
2024
Primary completion
2034
Study completion
2034
First posted
Sep 23, 2024
Registry last updated
Dec 10, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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