Molecular Studies and Clinical Correlations in Human Prostatic Disease

The Genitourinary Oncology/Urology Services at Memorial Sloan-Kettering Cancer Center (MSKCC) participates in research for the control, treatment, and cure of cancer. The purpose of this study is to collect normal and cancerous tissues, in addition to blood, and other body fluid samples from men with prostate cancer or prostatic disease. These samples may be stored for future use or used immediately by researchers who study prostate cancer and try to find better ways to diagnose, prevent, and treat it. We will look for genetic changes and protein markers on these cells. We hope to learn more about what makes some people get prostate cancer, why some cancers are more aggressive than others, and why some cancers respond to or resist different treatments. We may also try to grow the tumor cells in the lab. We may find a new treatment for prostate cancer based on this research.

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This study is active but is not currently recruiting participants.

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Key information

Conditions

Prostate Cancer Genital Diseases Genital Diseases, Male Genital Neoplasms, Male Male Urogenital Diseases Neoplasms Neoplasms by Site Prostatic Diseases Prostatic Neoplasms Urogenital Diseases Urogenital Neoplasms

Sex eligibility

Male

Study type

Observational

Primary location

Memorial Sloan Kettering Cancer Center

New York, 10065, United States

About this study

The therapeutics program for advanced prostate cancer is based on the hypothesis that the factors contributing to and associated with progression change as the disease evolves. To categorize these changes we now consider the disease as a series of states. 1 The states represent points where an intervention might be considered to prevent cancer from developing, to eliminate established disease, or to delay progression. The states also represent clinically significant milestones that can be used to assess treatment effects.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Men with prostate conditions representing the following disease states:

No Cancer Diagnosis
Clinically Localized Disease
Rising PSA
Clinical Metastases: Noncastrate
Clinical Metastases: Castrate (Testosterone ≤ 50 ng/ml)
Signed informed consent

Exclusion criteria

-Patients without any prostate related problems.

Sponsors and collaborators

Lead sponsor

Memorial Sloan Kettering Cancer Center

Other

Collaborators

Advanced Cell Diagnostics
ApoCell, Inc.
Array Genomics
Beckman Coulter GmbH
Biocept, Inc.
Bioview, Inc.
Broad Institute of MIT and Harvard
Brooklyn ImmunoTherapeutics, LLC
Clearbridge BioMedics Pte Ltd., Singapore
Cold Spring Harbor Laboratory
Creatv Microtech, Inc.
Cynvenio Biosystems
Dana-Farber Cancer Institute
Duke University
Epic Sciences
Exosome Diagnostics, Inc.
Flinders Medical Centre
Fluxion Biosciences
Foundation Medicine
Fred Hutchinson Cancer Center
Gen-Probe, Incorporated
Genentech, Inc.
General Electric
Ikonysis
Innocrin Pharmaceuticals Inc.
Institute of Cancer Research, United Kingdom
Janssen Diagnostics, LLC
Johns Hopkins University
M.D. Anderson Cancer Center
Massachusetts Institute of Technology
Nodality
Ohio State University
Oregon Health and Science University
Palo Alto Research Center
Promega Corporation
Purdue University
Rarecells
Rockefeller University
Rutgers Cancer Institute of New Jersey
Serametrix Corporation
Silicon Biosystems
The Scripps Research Institute
University of California, San Francisco
University of Chicago
University of Michigan
University of Minnesota
University of Regensburg
University of Southern California
University of Washington
University of Wisconsin, Madison
Universitätsklinikum Hamburg-Eppendorf
Viatar LLC
Vitatex Inc.
Weill Medical College of Cornell University

Registry information

Important dates

Study start: 1990
Primary completion: 2026
Study completion: 2026
First posted: Dec 21, 2007
Registry last updated: Mar 9, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

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