Molecular Modulation of the Growth Plate

The researchers are trying to identify molecular mechanisms that control growth plate mediated limb growth and identify agents that can be used to enhance or slow growth.

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Key information

Conditions

Growth Plate Injury Fracture Dislocation Fractures, Bone Joint Diseases Joint Dislocations Musculoskeletal Diseases Salter-Harris Fractures Wounds and Injuries

Sex eligibility

All sexes

Study type

Observational

Primary location

Mayo Clinic'

Rochester, Minnesota, 55905, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Skeletally immature children/adults undergoing surgical procedures where growth plate cartilage is removed as a normal part of their procedure; or patients undergoing surgical procedures where bone is removed as a normal part of their procedure.

Exclusion criteria

Skeletally mature children/adults

Treatment and study plan

Primary outcomes

RNA expression

Time frame: End of Study (1/2019

Measure RNA levels in growth plate tissue samples (ng/mL)

Sponsors and collaborators

Lead sponsor

Mayo Clinic

Other

Registry information

Important dates

Study start: 2013
Primary completion: 2026
Study completion: 2026
First posted: Apr 18, 2018
Registry last updated: Dec 18, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Active, Not Recruiting