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NCT Number: NCT06922474

Molecular Epidemiology of Enteroviruses Detected at the Virology Laboratory of Brest University Hospital During the Period 2018-2024: Retrospective Analysis of an Atypical Meningitis Epidemic in 2024 (BrEcho9Men)

This study is being done to learn more about enterovirus infections detected in the cerebrospinal fluid of patients at CHU de Brest. Researchers will analyze medical records and laboratory data collected between 2018 and 2024. They will look at how these infections present in patients, and whether a specific virus type, called Echo-9, may be associated with different clinical features or represent an emerging variant.

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This study is active but is not currently recruiting participants.

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Key information

Conditions

Enterovirus Infections Central Nervous System Diseases Central Nervous System Infections Central Nervous System Viral Diseases Echovirus 9 Infections Meningitis Meningitis Enterovirus Meningitis, Viral Nervous System Diseases Neuroinflammatory Diseases Picornaviridae Infections RNA Virus Infections Virus Diseases

Age range

0 day–100 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Chu Brest

Brest, 29200, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Cerebrospinal fluid (CSF) sample positive for enterovirus by RT-PCR between January 1, 2018 and December 31, 2024 , performed at the virology laboratory of CHU de Brest.
  • No documented opposition to the use of medical data for research purposes.

Exclusion criteria

  • Patients under legal protection (guardianship, curatorship, etc.)
  • Refusal to participate in the study

Treatment and study plan

Primary outcomes

  1. Phylogenetic analysis of Echo-9 strains detected between 2018 and 2024

    Time frame: January 1, 2018 to December 31, 2024

    Molecular characterization and phylogenetic comparison of Echo-9 strains detected at CHU de Brest and throughout France between January 1, 2018 and December 31, 2024, to identify a possible emerging variant.

Secondary outcomes

  1. Temporal distribution of enterovirus infections documented at CHU de Brest

    Time frame: January 1, 2018 to December 31, 2024

    Weekly quantification of enterovirus-positive cases (by RT-PCR) detected at CHU de Brest from 2018 to 2024. Comparison with national surveillance data from the French National Reference Center to detect atypical epidemic peaks, with a focus on 2024.

  2. Clinical characteristics of enterovirus-positive CSF cases

    Time frame: January 1, 2018 to December 31, 2024

    Among patients with cerebrospinal fluid samples positive for enterovirus between 2018 and 2024, clinical features will be described, including headache intensity, clinical severity, infection site (CSF, throat, stool, nasopharyngeal samples), and use of morphine. Subgroup comparisons may be conducted according to enterovirus genotype and year of infection, depending on the results of molecular typing.

  3. Biological characteristics of enterovirus-positive CSF samples

    Time frame: January 1, 2018 to December 31, 2024

    Among patients with cerebrospinal fluid samples positive for enterovirus between 2018 and 2024, biological parameters from positive samples will be described. For cerebrospinal fluid samples, variables include white blood cell count with differential, protein level, and the cerebrospinal fluid to blood glucose ratio. The presence or absence of additional positive samples (throat, stool, nasopharyngeal swabs) will also be documented.

Sponsors and collaborators

Lead sponsor

University Hospital, Brest

Other

Registry information

Official study title

Molecular Epidemiology of Enteroviruses Detected at the Virology Laboratory of Brest University Hospital During the Period 2018-2024: Retrospective Analysis of an Atypical Meningitis Epidemic in 2024

Acronym: BrEcho9Men

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Apr 10, 2025
Registry last updated
Apr 10, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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