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OpenTrials
Enrolling by Invitation

NCT Number: NCT03492372

Molecular Characterization of Spinal Tissue

The researchers are trying to identify molecular mechanisms that control spine deformity and degenerative changes that can be used for therapeutic strategies.

Enrolling by Invitation

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Key information

Conditions

Spinal Diseases Bone Diseases Musculoskeletal Diseases

Age range

1 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Mayo Clinic

Rochester, Minnesota, 55905, United States

About this study

Discarded surgical material from spinal procedures is collected. RNA analysis and other tests on the tissue is performed to determine markers of pathologic disease and to develop pharmacologic treatment strategies for pediatric spinal disorders.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Children and adults undergoing surgical procedures where spinal tissues are removed as a normal part of their procedure. Material from adults may be collected as a control group.

Exclusion criteria

  • Surgeries where spinal tissues are not being removed.

Treatment and study plan

Waste tissues are collected at the time of spinal surgery.

Other

This is a single visit study. Waste tissues are collected at the time of spinal surgery.

Primary outcomes

  1. RNA expression

    Time frame: Baseline

    Measure RNA levels in spinal tissues samples (ng/mL)

Sponsors and collaborators

Lead sponsor

Mayo Clinic

Other

Registry information

Important dates

Study start
2015
Primary completion
2026
Study completion
2026
First posted
Apr 10, 2018
Registry last updated
Sep 19, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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