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NCT Number: NCT06357507

Molecular Characterization of Moraxella Catarrhalis From Pneumonic Children at Pediatric Assiut University Hospital

moraxella catarrhalis is responsible for respiratory tract infection in children and adults with streptococcus pneumonia and haemophilus influenza.Moraxella catarrhalis is gram negative diplococci, non-motile and non spore bearing bacteria. Until, 1995 it was considered as a non pathogenic respiratory tract flora.This bacteria is an important pathogen and a common cause of both upper and lower respiratory tract infections, pneumonia, sinusitis and conjunctivitis in infants, children and in elderly patients. In adults, M. catarrhalis also causes chronic obstructive pulmonary disease (COPD) and pneumonia. However, it is associated with a number of respiratory infections affecting both children and adults, including laryngitis, bronchitis and pneumonia .

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Key information

Conditions

Respiratory Tract Infections Infections Respiratory Tract Diseases

Age range

1 month and older

Sex eligibility

All sexes

Study type

Observational

About this study

This institution is polymicrobial community with other pathogens such as Streptococcus pneumoniae and Haemophilus influenza (Sethi and Murphy, 2008). The pathogenicity of M. catarrhalis is mediated by several virulence genes, including the ubiquitous surface protein genes A1 (uspA1) and A2 (uspA2), which encode virulence factors that promote colonization and successful host infections (Bernhard S et al.,2012).Bacterium was first isolated in 1896, it was considered to be a harmless commensal of the upper respiratory tract for a long period of time. The bacterium rapidly colonizes the nasopharynx soon after birth asymptomatically (Blakeway et al., 2017).

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • all children with bacterial pneumonia

Exclusion criteria

  • viral pneumonia , tuberculosis and immunocompromised

Treatment and study plan

Primary outcomes

  1. isolation of moraxella catarrhalis

    Time frame: 3 years

    isolation of organism on muller hinton agar

Secondary outcomes

  1. detection of virulence genes of moraxella catarrhalis

    Time frame: 3 years

    detection of virulence genes by PCR

  2. detetion of antibiotic resistance

    Time frame: 3years

    detetion of antibiotic resistance by agar disc diffusion

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Official study title

Molecular Characterization of Moraxella Catarrhalis Isolates From Pneumonic Children at Pediatric Assiut University Hospital

Acronym: Mcatarrhalis

Important dates

Study start
2024
Primary completion
2027
Study completion
2027
First posted
Apr 10, 2024
Registry last updated
Apr 16, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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