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NCT Number: NCT07116356

Molecular Characterization of Carbapenemase-Producing Enterobacterales

Bacterial infections with carbapenem resistant pathogens are one of the major threats in immunocompromised patients, especially among cancer patients .Furthermore, Gram negative pathogens are becoming increasingly prevalent and have become an ongoing global health concern .Emergence of Gram-negative pathogens, especially Enterobacterales that avert many of the human defense mechanisms are alarmingly increasing and most of these pathogens are resistant to many of the in-use antibiotics including carbapenems .

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Key information

Conditions

Acute Myeloid Leukemia Hematologic Diseases Hemic and Lymphatic Diseases Leukemia Leukemia, Myeloid Leukemia, Myeloid, Acute Neoplasms Neoplasms by Histologic Type

Age range

4 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All patients admitted to Sohag Oncology Center have different infections and isolated organism one of carbapenem resistant enterobacterales detected by antibiotic sensitivity test.

Exclusion criteria

  • All patients admitted to Sohag Oncology Center having infections in different sites and isolated organisms are not one of enterobacterales and not carbapenem resistant.

Treatment and study plan

Antibiotic administration

Diagnostic Test

different samples were collected from patients admitted at oncology center at sohag

Molecular detection of antibiotic resistance

Diagnostic Test

Molecular detection of carbapenem resistant genes:

  • Extraction of nucleic acid from isolated organisms by boiling.
  • Primers will be used for detection of carbaenem resistant genes

Primary outcomes

  1. Isolation of causative organism

    Time frame: 6 months

Secondary outcomes

  1. Antibitic sensitivity test:

    Time frame: 2 months

  2. Molecular detection of carbapenem resistant genes:

    Time frame: 3 months

Study contacts

Contact information is provided by the study sponsor or research team.

Noha Saber Shafik, Assistant professor

CONTACT

[email protected]

+201067261504

Sponsors and collaborators

Lead sponsor

Sohag University

Other

Registry information

Official study title

Molecular Characterization of Carbapenemase-Producing Enterobacterales Isolated From Clinical Samples in Egypt

Important dates

Study start
2025
Primary completion
2025
Study completion
2026
First posted
Aug 11, 2025
Registry last updated
Aug 11, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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