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OpenTrials
Completed

NCT Number: NCT02615756

Molecular and Functional Neurobiology of Physical Exercise

In this study, we use positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) to study brain mechanisms that contribute to physical exercise-induced reward. We examine whether acute physical exercise releases endogenous opioids in the brain, and whether it modulates brain responses to viewing appetizing foods. Unraveling these mechanism are instrumental from a public health perspective, given the undisputed positive health effects of physical exercise.

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Key information

Conditions

Physical Exercise Behavior (Liking/Aversion)

Age range

18 year–65 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Turku PET Centre

Turku, 20810, Finland

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Native Finnish speaker
  • Age > 18 years
  • Western Caucasian origin

Exclusion criteria

  • Age < 18 or > 65
  • History or current mental disorder
  • BMI > 27 kg/m2
  • Use of drugs that influence the central nervous system, including nicotine
  • Poor compliance
  • Any chronic medical defect or injury which hinder or interfere everyday life
  • Eating disorder
  • Current or past excessive use of alcohol or substance abuse
  • Past dose of radiation from medical research such that the annual effective dose will exceed 10 mSv
  • Any other condition that in the opinion of the investigator could create a hazard to the subject safety, endanger the study procedures or interfere with the interpretation of study results
  • Presence of any ferromagnetic objects that would make MR imaging contraindicated

Treatment and study plan

Exercise

Behavioral

Primary outcomes

  1. Binding of [11C]carfentanil in brain confirmed by positron emission tomography

    Time frame: Baseline and 20 min after physical exercise completion

    Change in binding of [11C]carfentanil in baseline and 20 min after physical exercise completion

Sponsors and collaborators

Lead sponsor

Turku University Hospital

Other Gov

Collaborators

  • Academy of Finland
  • Juho Vainio Foundation
  • Novo Nordisk A/S
  • University of Turku

Registry information

Acronym: EXEBRAIN

Important dates

Study start
2013
Primary completion
2018
Study completion
2018
First posted
Nov 26, 2015
Registry last updated
Mar 9, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.