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NCT Number: NCT07293507

MOE and DNSE Effects on Balance and Activities of Daily Living Diabetic Peripheral Neuropathy

The purpose of this study is to compare the impact of Modified Otago Exercises and Dynamic Neuromuscular Stabilization Exercises on patients with diabetic peripheral neuropathy (DPN) using valid tools such as the Berg Balance Scale and the Katz Index of Independence in ADL. The results of our study will be helpful for clinical decision-making in terms of selecting specific physiotherapy treatment techniques in an attempt to improve their function, reduce their falls, and improve their independence specific to diabetes neuropathy.

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Key information

Conditions

Diabetes Mellitus Type 2 Diabetes Mellitus Diabetes Mellitus, Type 2 Endocrine System Diseases Glucose Metabolism Disorders Metabolic Diseases Nutritional and Metabolic Diseases

Age range

60 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

imran idrees teaching hospital daska Road sialkot, Dar ul shifa hospital sialkot

Sialkot, Punjab Province, 51310, Pakistan

Location contact

Sana Riaz, Nmpt

CONTACT

[email protected]

+92 347 4716107

Sana Riaz, Nmpt

SUB_INVESTIGATOR

Zunaira Saleem Butt, Ms-NMPT

PRINCIPAL_INVESTIGATOR

About this study

Research into therapeutic exercise for patients with diabetic peripheral neuropathy (DPN) has grown over the past decade due to the increasing recognition of non-pharmacological strategies for reducing fall risk and restoring function. DPN is associated with altered gait, diminished proprioception, and increased postural sway, making balance-specific exercise programs a critical area of intervention.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 60 years of age and elderly.
  • The Timed Up and Go score exceeds 10 seconds.
  • Both men and women
  • Individuals with type 2 diabetes and DPN.
  • Patients diagnosed with diabetes from last 5 Years.
  • Patients diagnosed with diabetic peripheral neuropathy with scores ≥ 4 on Michigan Neuropathy Screening Instrument (MNSI)
  • Individuals with an ability to walk independently.

Exclusion criteria

  • Individuals with neuropathies that are not caused by diabetes.
  • Individuals with any neurological disorders that may affect their ability to balance.
  • Participants suffering from any musculoskeletal disorders that result in discomfort and instability.
  • A history of acute and chronic physiological, psychological, and mental disorders that may prevent exercise.
  • Participants with unrelated orthopedics, surgical, or health conditions that impair physical movement and equilibrium, such as severe diabetic retinopathy were eliminated, as were those with active foot issues.
  • Patients having serious complications of diabetes, such as amputation and patients who are unable to complete the entire program.

Treatment and study plan

modified otago exercises

Other

The 30-minute Otago Exercise Program, involving both balance and strength training, followed by further 15 minutes of walking as part of the modified-OEP group intervention will be given. The 15-minute walk will be completed by walking continuously at an appropriate pace in the approximately 15-meter exercise room. Participants will be told to walk 15 meters, execute a U-turn to the left, walk 15 meters, and then execute a U-turn to the right at the next turning point to create the same effect on the stated benefit of symmetry while turning left and right. For twelve weeks, the intervention will be given three times a week.

Dynamic Neuromuscular Stabilization Exercises

Other

The Dynamic neuromuscular stabilization exercises (DNS) twice a week for 60 minutes each time for 12 weeks. A five-minute warm-up, a fifty-minute exercise plan, and a five-minute cool-down comprised the program. Static stretching was used for the cool-down and dynamic stretching for the warm-up. DNS training is conducted in three levels. Level 1 (1 to 4 weeks) includes: (1) dynamic stretching (2) baby rock (3) breathing (4) rolling. Level 2 (5 to 8 weeks) includes: (1) oblique sit (2) aqua bag tripod (3) aqua bag sitting (4) aqua bag kneeling. Level 3 (9 to 12 weeks) include: (1) aqua bag high kneeling (2) static stretching (3) aqua bag standing

Primary outcomes

  1. Katz Index of Independence in Activities of Daily Living

    Time frame: Baseline, after 6th week, after 12th week

    The Katz Index of Independence in Activities of Daily Living (ADL) is a tool that assesses a person's ability to perform six basic self-care tasks: bathing, dressing, toileting, transferring, continence, and feeding

  2. Berg Balance Scale

    Time frame: Baseline, After 6th week, After 12th week

    The Berg Balance Scale (BBS) is a 14-item test that assesses an individual's static and dynamic balance through a series of tasks, such as sitting to standing, reaching, and turning.

Study contacts

Contact information is provided by the study sponsor or research team.

Imran Amjad Amjad, PhD

CONTACT

[email protected]

+92 324390125

Sponsors and collaborators

Lead sponsor

Riphah International University

Other

Registry information

Official study title

Effects of Modified Otago Exercises Versus Neuromuscular Dynamic Stabilization Exercises on Balance and Activities of Daily Living in Patients With Diabetic Peripheral Neuropathy

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Dec 19, 2025
Registry last updated
Dec 19, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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