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Completed

NCT Number: NCT02022176

Modulation of Metabolic Rate by Inorganic Nitrate

The purpose of this study is to determine the effects of sodium nitrate on resting metabolic rate, glucose uptake and formation of reactive oxygen species in humans.

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Key information

Conditions

Resting Metabolic Rate Glucose Metabolism Disorders Hyperinsulinism Insulin Resistance Metabolic Diseases Nutritional and Metabolic Diseases

Age range

18 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Karolinska Institutet

Stockholm, 17177, Sweden

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Healthy volunteers

Exclusion criteria

Chronic medication Vegetarian Nicotine Users Known metabolic disease

Treatment and study plan

Glucose Uptake

Other

Glucose uptake is measured by oral glucose tolerance test and euglycemic clamp

Resting metabolic rate

Other

Resting metabolic rate is measured by indirect calorimetry after an over-night fast

Nitrite infusion

Other

Sodium nitrite or saline was infused at escalating doses at a rate of 1, 10 or 100 nmol kg-1 min-1 (10 minutes per dose) in a randomized, double blinded cross-over fashion

Primary outcomes

  1. Resting metabolic rate

    Time frame: day 4

    Resting metabolic rate, measured after overnight fast using indirect calorimetry

Secondary outcomes

  1. Thyroid hormone status

    Time frame: day 4

  2. Glucose uptake

    Time frame: day 4

    Glucose uptake measured with oral glucose tolerance test and euglycemic clamp

  3. Nitrite infusion

    Time frame: 30 minutes

    Effect on resting metabolic rate when infusing escalating intravenous doses of sodium nitrite or saline solution

Sponsors and collaborators

Lead sponsor

Karolinska Institutet

Other

Collaborators

  • Swedish Heart Lung Foundation
  • The Swedish Research Council

Registry information

Official study title

Dietary Inorganic Nitrate: Effects on Metabolic Rate, Reactive Oxygen Species Production, Glucose Uptake and Primary Myotube Respiration.

Important dates

Study start
2008
Primary completion
2013
Study completion
2013
First posted
Dec 27, 2013
Registry last updated
Jan 3, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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