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Completed

NCT Number: NCT00390507

Modification of Posttetanic Count (PTC) for Monitoring Deep Neuromuscular Block II

The purpose of this study is to examine the relationship between post-tetanic count (PTC) and time to first response to Train of four (TOF) stimulation during deep neuromuscular blockade induced by rocuronium.

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Key information

Conditions

Neuromuscular Blockade

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Dep. of Anesthesia, Rigshospitalet, Copenhagen, Denmark

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Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • ASA 1-3
  • General anaesthesia >1 hour
  • Surgery in supine position with possibility of monitoring the neuromuscular blockade at the thumb (n.ulnaris stimulation).
  • Written informed content

Exclusion criteria

  • Neuromuscular disorders, hepatic and renal dysfunction
  • Medication expected to interfere with the neuromuscular blocking agent
  • Allergy to any medication used during anaesthesia
  • Body weight less or exceeding 20% of the ideal body weight
  • Pregnancy or breastfeeding

Treatment and study plan

Post-tetanic count frequency

Procedure

Primary outcomes

  1. Time to first response to TOF stimulation (T1)

Secondary outcomes

  1. Time to second response to TOF stimulation (T2)

  2. Time to first post-tetanic count (PTC)

  3. Number of post-tetanic count at first response to TOF

  4. Time to T1=25%

  5. Interval 25-75%

  6. Time to TOF 0.9

  7. Time to TOF 1.0

Sponsors and collaborators

Lead sponsor

Rigshospitalet, Denmark

Other

Registry information

Important dates

Study start
2006
Primary completion
2010
First posted
Oct 20, 2006
Registry last updated
Sep 6, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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