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Completed

NCT Number: NCT06826508

Modes of Delivery Impact Maternal Oxidative Stress Biomarkers and Dynamic Thiol Disulphide Homeostasis

Modes of delivery impact maternal oxidative stress biomarkers and dynamic thiol disulphide homeostasis

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Key information

Conditions

Vaginal Delivery Cesarian Section Oxidative Stress

Age range

20 year–36 year

Sex eligibility

Female

Study type

Observational

Primary location

Alanya Training and Research Hospital Gynecology and Obstetrics Department

Antalya, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

For VD group:

  • Women with spontaneous uncomplicated vaginal delivery
  • Women who were in the 38th week and vertex presentation and whose contractions had started naturally.

For CS group:

  • Women in their 38th week of pregnancy who delivered by elective CS without uterine contractions

Exclusion criteria

  • Participants who were smokers
  • Participants who had a non-optimal pre-pregnancy body mass index
  • Systemic diseases such as diabetes mellitus and gestational hypertension.

Treatment and study plan

Primary outcomes

  1. Oxidative stress markers

    Time frame: From January 2021 to August 2021

    Total antioxidation state (μmol Trolox equivalent/ L),

  2. Oxidative stress markers

    Time frame: From January 2021 to August 2021

    Total oxidation status(μmol H2O2 equivalent/L)

  3. Oxidative stress markers

    Time frame: From January 2021 to August 2021

    Oxidative stress index (arbitrary unit)

  4. Oxidative stress markers

    Time frame: From January 2021 to August 2021

    Disulfide (-S-S-) (µmol / L) / alb (g / l)

  5. Oxidative stress markers

    Time frame: From January 2021 to August 2021

    Total thiol (µmol / L)

  6. Oxidative stress markers

    Time frame: From January 2021 to August 2021

    Native thiol (µmol / L) / alb (g / l)

  7. Oxidative stress markers

    Time frame: From January 2021 to August 2021

    Ischemia modified albumin (U/L)

  8. Oxidative stress markers

    Time frame: From January 2021 to August 2021

    Paroxanase (U/L)

  9. Oxidative stress markers

    Time frame: From January 2021 to August 2021

    Arylesterase (Ku/l)

Sponsors and collaborators

Lead sponsor

Mardin Artuklu University

Other

Collaborators

  • Alanya Alaaddin Keykubat University

Registry information

Important dates

Study start
2021
Primary completion
2021
Study completion
2021
First posted
Feb 14, 2025
Registry last updated
Feb 14, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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