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NCT Number: NCT07662876

Moderate Intensity vs High Intensity Interval Training in Women With Heart Failure

* To determine the effects of moderate intensity exercise vs high intensity interval training on functional capacity in women with heart failure * To determine the effects of moderate intensity exercise vs high intensity interval training on quality of life in women with heart failure

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Key information

Conditions

Heart Failure Cardiovascular Diseases Heart Diseases

Age range

40 year–70 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Riphah International University

Islamabad, Fedral, 44000, Pakistan

Location contact

Dua Yasin, MSPT*

CONTACT

[email protected]

+92 318 5084334

Dua Yasin, MSPT*

PRINCIPAL_INVESTIGATOR

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Women aged 40-70 years, diagnosed with Stable Heart Failure (NYHA class II or III).
  • Clinically stable patients referred for exercise-based cardiac rehabilitation by the physician.
  • Able to perform exercise testing (able to walk 150 meters on the six-minute walk test) before starting the program.
  • Women willing to participate and provide informed consent.

Exclusion criteria

  • Unstable Heart failure or myocardial infarction (< 4 weeks).
  • Severe arrhythmias, uncontrolled hypertension, or ongoing chest pain during exercise.
  • Orthopedic, neurological, or cognitive limitations preventing safe exercise participation.
  • Any medical contraindication to exercise testing.
  • Refusal or inability to provide informed consent or comply with the rehabilitation program.

Treatment and study plan

moderate-intensity aerobic training

Other

Group A will undergo a moderate-intensity aerobic training program as part of a structured cardiac rehabilitation protocol. The program will be supervised sessions, conducted three times per week for 12 weeks. Each session will include approximately 30 minutes of aerobic exercise performed on a bicycle ergometer at an intensity of 60% of heart rate reserve (HRR)

High-intensity interval training

Other

Group B will perform a high-intensity interval training (HIIT) program designed according to established cardiac rehabilitation protocols. Bicycle ergometer will be used, in which each session will begin with a 10-minute warm-up (lower limb large muscle stretches), followed by intervals performed at 80% of heart rate reserve (HRR) for 3 min, alternating with recovery periods at low intensity 40% of HRR for 3 min. The total exercise duration will be approximately 30 minutes per session, conducted three times weekly for 12 weeks under supervision. Participants will be encouraged to maintain self-directed exercise after the intervention period

Primary outcomes

  1. Six-minute walk test

    Time frame: Baseline and 12 Week

    The Six-Minute Walk Test (6MWT) is a simple, submaximal test that evaluates functional capacity and exercise capacity in patients with chronic heart failure by measuring the distance walked and estimating peak VO2. It will be performed in a 30-meter corridor, where participants will walk as far as possible in six minutes, with heart rate and oxygen saturation monitored before and after the test. This study tested the validity and reliability of the six-minute walk test (6MWT) in cardiac rehabilitation patients, including those with heart failure.

  2. EuroQol 5-Dimension Questionnaire

    Time frame: Baseline and 12 week

    EuroQol 5-Dimension Questionnaire (EQ-5D): The EuroQol-5 Dimension (EQ-5D) is a questionnaire used to measure quality of life (QoL). It evaluates five key areas: mobility, self-care, usual activities, pain/discomfort, and anxiety/depression. Each area has one question, and responses together describe a person's overall health status. For the 5L, scores range from 5 to 25. A lower score indicates better health, while a higher score indicates greater health problems. Patients rate their overall health TODAY on a vertical scale from 0 (worst imaginable health) to 100 (best imaginable health)

Study contacts

Contact information is provided by the study sponsor or research team.

Muhammad Iqbal Tariq

CONTACT

[email protected]

333826752

Sponsors and collaborators

Lead sponsor

Riphah International University

Other

Registry information

Official study title

Effects of Moderate Intensity Exercise vs High Intensity Interval Training on Functional Capacity and Quality of Life in Women With Heart Failure

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Jun 23, 2026
Registry last updated
Jun 23, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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