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NCT Number: NCT06918158

Mobilization With Movement Versus Joint-Specific Manipulation in De Quervain's Tenosynovitis

A comparative study on the effectiveness of mobilization with movement (MWM) versus joint-specific manipulation (JSM) in patients with De Quervain's tenosynovitis typically aims to assess how each technique impacts pain relief and functional improvement. De Quervain's tenosynovitis is an inflammation of the tendons around the thumb and wrist, often causing pain, swelling, and difficulty in performing everyday tasks. The study would likely compare the two interventions by measuring pain levels, range of motion, and overall functional outcomes before and after treatment. MWM involves applying specific, controlled movements while the patient is actively engaging in their joint motion, targeting the tissue's mobility and reducing pain. JSM, on the other hand, focuses on manipulating the joint directly to restore normal function, specifically targeting the wrist and thumb regions affected by the condition.

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Key information

Conditions

Tenosynovitis Muscular Diseases Musculoskeletal Diseases Tendinopathy

Age range

18 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Riphah international University Malakand Campus

Malakand, KPK, 23060, Pakistan

About this study

A comparative study on the effectiveness of Mobilization with Movement (MWM) versus Joint-Specific Manipulation (JSM) in patients with De Quervain's Tenosynovitis would delve deeper into the physiological mechanisms and clinical outcomes associated with each technique, providing valuable evidence for therapeutic decision-making. De Quervain's Tenosynovitis is a condition characterized by the inflammation of the tendons at the base of the thumb, particularly affecting the abductor pollicis longus and extensor pollicis brevis tendons. This condition is commonly caused by repetitive strain, overuse, or trauma, leading to pain, swelling, and restricted movement, which significantly impacts the patient's daily activities.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

o Patients clinically diagnosed with De Quervain's tenosynovitis

  • Age between 25-45 years.
  • Positive Finkelstein test.
  • Pain over the first dorsal compartment.
  • Limited wrist and thumb function.
  • Willingness to take part and adhere to the study's guidelines.

Exclusion criteria

Participants fall in this category would be excluded of the study.

  • Previous surgery of wrist or thumb.
  • Presence of neurological symptoms like numbness, weakeness.
  • Rheumatological conditions like rheumatoid arthritis.
  • Pregnancy.
  • Presence of wrist fracture or osteoporosis.
  • Carpel tunnel syndrome.

Treatment and study plan

mobilization with movement

Other

Mobilization with Movement

  • The proximal row of carpals glides passively radially.
  • Active thumb and wrist movements superimposed on the glide.

Therapeutic excercises:

  • Ball Toss
  • Static web gripping
  • Gentle ROM activities to maintain mobility
  • Isometric exercises in all direction

Joint Specific Manipulation

Other

Joint Specific Manipulation

  • High-velocity, low-amplitude thrust to the first carpometacarpal joint
  • Radiocarpal wrist mobilization .Grade III-IV applied at end range. 2. Therapeutic excercises:
  • Ball Toss
  • Static web gripping
  • Gentle ROM activities to maintain mobility
  • Isometric exercises in all direction Ergonomics modifications

Primary outcomes

  1. Pain Reduction - Measured using the Numeric Pain Rating Scale (NPRS) (0-10 scale).

    Time frame: 6 Months

    Pain intensity will be assessed using the Numeric Pain Rating Scale (NPRS), a validated tool where participants rate their pain on a scale from 0 no pain to 10 worst possible pain.

Secondary outcomes

  1. Wrist Function - Assessed with the Patient-Rated Wrist Evaluation (PRWE) (0-100 scale).

    Time frame: 6months

    Functional wrist use will be assessed using the Patient-Rated Wrist Evaluation (PRWE), which evaluates pain and disability on a 100-point scale, with higher scores indicating greater impairment. Clinical signs will be assessed using Finkelstein's Test, a standard diagnostic test for De Quervain's tenosynovitis, recorded as positive or negative. Data will be analyzed using pre- and post-intervention comparisons within and between groups to determine the effectiveness of each intervention.

Other outcomes

  1. Clinical Signs - Evaluated using Finkelstein's Test (Positive/Negative).

    Time frame: 6 months

    Clinical Signs will be assessed using Finkelstein's Test, recorded as positive or negative based on the presence of pain during the maneuver.

Sponsors and collaborators

Lead sponsor

Riphah International University

Other

Registry information

Official study title

Comparative Study on the Effectiveness of Mobilization With Movement Versus Joint Specific Manipulation on Pain and Function in Patient With Dequervains Tenosynovitis

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Apr 9, 2025
Registry last updated
Apr 25, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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