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OpenTrials
Completed

NCT Number: NCT03059771

Mobile Enhancement of Motivation in Schizophrenia

Motivation deficits are a strong determinant of poor functional outcomes in people with schizophrenia. Mobile interventions are a promising approach to improving these deficits, as they can provide frequent cues and reinforcements that support goal-directed behavior. The primary aims of this study are to conduct a pilot study using a randomized design to 1) Test the feasibility and acceptability of a personalized mobile text message intervention, Mobile Enhancement of Motivation in Schizophrenia (MEMS) and to 2) Test the preliminary effectiveness of MEMS compared to a control condition.

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Key information

Conditions

Schizophrenia Mental Disorders Psychosis Psychotic Disorders Schizo Affective Disorder Schizophrenia Spectrum and Other Psychotic Disorders

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Midtown Community Mental Health Center

Indianapolis, Indiana, 46208, United States

About this study

Objectives: Motivation deficits are one of the strongest determinants of poor functional outcomes in people with schizophrenia. Mobile interventions are a promising approach to improving these deficits, as they can provide frequent cues and reinforcements that support goal-directed behavior. The objective of this study is to conduct a pilot study using a randomized design to 1) Test the feasibility and acceptability of a personalized mobile text message intervention, Mobile Enhancement of Motivation in Schizophrenia (MEMS) and to 2) Test the preliminary effectiveness of MEMS compared to a control condition. Methods: Up to forty outpatients with a schizophrenia-spectrum disorder will be recruited. All participants will set individualized recovery goals to complete over an eight-week period; those randomized to receive MEMS will also receive three sets of personalized, interactive text messages each weekday to reinforce and cue goal completion. Before and after the eight-week period, participants in both groups will complete validated measures of motivation. Both groups will also report their goal attainment after eight weeks. Results: It is anticipated that those in the MEMS group will demonstrate greater goal attainment and improvements in motivation compared to the control group. Discussion: This project will test the initial feasibility, acceptability, and effectiveness of a novel intervention for improving one of the most debilitating aspects of schizophrenia.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Schizophrenia-spectrum diagnosis
  • Have a text-message enabled cell-phone
  • Are a current client at a participating community mental health center
  • Are in a non-acute phase of illness or have no medication changes or hospitalizations in the prior 30 days
  • Demonstrate a minimum of moderate motivation impairments according to the Clinical Assessment Interview for Negative Symptoms (CAINS; Kring et al., 2013)
  • Have an English reading level at or above the fourth grade according to the Graded Word List (Pray & Ross, 1969)

Treatment and study plan

Mobile Enhancement of Motivation (MEMS)

Behavioral

The MEMS group will engage in a goal-setting session and then receive personalized text-messages to support goal attainment.

Control

Behavioral

The control group will only engage in a goal-setting session.

Primary outcomes

  1. Goal completion

    Time frame: follow-up (8 weeks)

    The percentage of baseline goals participants completed over the eight-week period will be assessed at the follow-up assessment.

Secondary outcomes

  1. Motivation and Pleasure Scale-Self-Report (MAP-SR)

    Time frame: baseline and follow-up (8 weeks)

    The MAP-SR is a self-report measure 15-item self-report measure that assesses participant's level of motivation and pleasure in several domains, including work and recreational activities. It has been found to be valid and reliable in a schizophrenia-spectrum sample (Llerena, et al., 2013).

  2. Intrinsic Motivation Index

    Time frame: baseline and follow-up (8 weeks)

    The 3-item Intrinsic Motivation Index (Nakagami et al., 2008) from the clinician-rated Quality of Life Scale (Heinrichs et al., 1984) will be used to assess trait-like intrinsic motivation.

Sponsors and collaborators

Lead sponsor

Indiana University

Other

Collaborators

  • American Psychological Foundation
  • Indiana Clinical and Translational Sciences Institute
  • Indiana University-Purdue University Indianapolis Department of Psychology

Registry information

Official study title

Mobile Enhancement of Motivation in Schizophrenia: A Pilot Trial of a Personalized Text Message Intervention for Motivation Deficits

Important dates

Study start
2017
Primary completion
2018
Study completion
2018
First posted
Feb 23, 2017
Registry last updated
Jul 30, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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