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Active, Not Recruiting

NCT Number: NCT06587568

Mobile Chat Messaging for Alcohol Reduction in Patients With Chronic Liver Diseases

The goal of this pilot randomized controlled trial is to evaluate the trial feasibility and acceptability of mobile chat messaging for reducing alcohol use among patients with chronic liver diseases. Specific objectives include:

1. To assess whether the eligibility criteria were too restrictive by estimating the eligibility rate 2. To assess how many eligible CLD patients accepted the invitation to participate in the trial 3. To assess the participant retention rate through 6 months after treatment initiation 4. To assess the intervention acceptability in terms of participants' engagement with and rating of the chat messaging intervention. 5. To assess the safety of the intervention 6. To estimate the intervention effect on alcohol use outcomes and liver functions 7. To synthesise data to inform the sample size calculation in the future definitive trial 8. To explore the participants' perception and experiences in the chat-based intervention

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

Chronic Liver Disease Digestive System Diseases Fibrosis Hepatitis Liver Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Queen Mary Hospital

Hong Kong

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age ≥18 years
  • Diagnosed with chronic liver disease
  • Alcohol Use Disorders Identification Test score ≥8
  • Own a smartphone with a mobile instant messaging app installed
  • Able to read and communicate in Chinese

Exclusion criteria

  • Having a psychiatric or psychological disease or on psychotropic drugs
  • Participating in other alcohol reduction or abstinence programmes
  • Require emergency or in-patient treatment after consultation

Treatment and study plan

Mobile chat messaging

Behavioral

A trained counsellor will interact with a participant individually and provide personalised alcohol reduction information and advice via a mobile instant messaging app in real time for 3 months from randomisation.

Screening, brief intervention and referral to treatment

Behavioral

Brief counselling (5 to 10 mins) to reduce drinking and a self-help booklet

Other names: SBIRT

Primary outcomes

  1. Recruitment rate

    Time frame: Through recruitment completion, about 8 months

    Number of participants divided by the number of eligible subjects

  2. Retention rate

    Time frame: 6 months after randomisation

    Number of participants completed the follow-up divided by the number of participants

  3. Weekly alcohol consumption

    Time frame: 6 months after randomisation

    Assessed by questions 1 and 2 of AUDIT-C

Secondary outcomes

  1. Eligibility rate

    Time frame: Through recruitment completion, about 8 months

    Number of eligible patients divided by the number of patients screened

  2. Weekly alcohol consumption

    Time frame: 3 months after randomisation

    Assessed by questions 1 and 2 of AUDIT-C

  3. Frequency of heavy episodic drinking

    Time frame: 3 months after randomisation

    Self-reported

  4. Frequency of heavy episodic drinking

    Time frame: 6 months after randomisation

    Assessed by question three of AUDIT-C

  5. AUDIT score and level

    Time frame: 3 months after randomisation

    Assessed by the Alcohol Use Disorders Identification Test

  6. AUDIT score and level

    Time frame: 6 months after randomisation

    Assessed by the Alcohol Use Disorders Identification Test

  7. Total alcohol consumption in the past week

    Time frame: 6 months after randomisation

  8. Past 7-day alcohol abstinence

    Time frame: 3 months after randomisation

    Self-reported

  9. Past 7-day alcohol abstinence

    Time frame: 6 months after randomisation

    Self-reported

  10. Past 30-day alcohol abstinence

    Time frame: 3 months after randomisation

    Self-reported

  11. Past 30-day alcohol abstinence

    Time frame: 6 months after randomisation

    Self-reported

  12. Past 7-day total alcohol consumption

    Time frame: 3 months after randomisation

    Measured in grams

Sponsors and collaborators

Lead sponsor

The University of Hong Kong

Other

Collaborators

  • Health and Medical Research Fund

Registry information

Official study title

Mobile Chat Messaging Plus Screening-based Brief Alcohol Intervention for Patients With Chronic Liver Diseases: a Pilot Randomised Controlled Trial

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Sep 19, 2024
Registry last updated
May 1, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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