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Completed

NCT Number: NCT04533204

Mnemonic Strategy Versus Spaced Retrieval Training in Those With Mild Cognitive Impairment

This study compared two active cognitive interventions to evaluate whether one improved memory more than the other in patients with mild cognitive impairment. Participants were randomized to either memory strategy training or spaced retrieval training and completed memory tests before and after 3 training sessions. Participants returned 1 month after treatment to see how well they remembered the learned information. Brain scans (functional MRI) were collected before and after the interventions to see if training changed the way brain regions were functioning.

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Key information

Conditions

Mild Cognitive Impairment Alzheimer Disease Brain Diseases Central Nervous System Diseases Cognition Disorders Cognitive Dysfunction Dementia Mental Disorders Nervous System Diseases Neurocognitive Disorders Neurodegenerative Diseases Tauopathies

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

VA Ann Arbor Healthcare System, Ann Arbor, MI

Ann Arbor, Michigan, 48105, United States

About this study

Individuals with MCI were randomized to 3 sessions of mnemonic strategy or spaced retrieval training that focused on object location associations. Across these training sessions, each group received 9 training trials for each of the 45 trained stimuli. Task-fMRI was acquired before and after training. Memory was again evaluated 1 month after the last training session. The primary outcome measure was memory for the "trained" stimuli while secondary outcome was accuracy for novel stimuli acquired outside of the MRI environment.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

-Diagnosis of MCI according to Petersen (2004) criteria, right handed

Exclusion criteria

  • Diagnosis of other neurological condition,
  • active drug/alcohol abuse/dependence,
  • moderate-severe depression or other Axis I diagnoses.

Treatment and study plan

mnemonic strategy training

Behavioral

training using mnemonic strategies

spaced retrieval training

Behavioral

training using spaced retrieval

Primary outcomes

  1. Percent of Correct Object Location Associations Assessed up to 1 Month Post-treatment

    Time frame: up to 1 month after last training session

    Change in memory for 45 trained object location associations

Secondary outcomes

  1. Change in Accuracy (vs. Baseline) on Novel Object Location Associations

    Time frame: up to 1 month after last training session

    Change in accuracy for novel object location associations using a touchscreen task; distance measured in cm from actual location

Sponsors and collaborators

Lead sponsor

VA Office of Research and Development

Fed

Registry information

Official study title

Comparing Mnemonic Strategy With Spaced Retrieval Training in Patients With Mild Cognitive Impairment (B6366-W)

Acronym: MST training

Important dates

Study start
2010
Primary completion
2014
Study completion
2014
First posted
Aug 31, 2020
Registry last updated
Mar 23, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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