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OpenTrials
Completed

NCT Number: NCT02109120

MMP-9 Monitoring Particulate Cerebral Embolisation

1. In carotid endarterectomy(CEA) surgery, the dynamic changes of plasma MMP9 concentration cross CEA will be identified. 2. And the part of patients suffered particulate cerebral embolic injury, their MMP9 level will increase in the early stage after CEA.

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Key information

Conditions

Cerebral Embolic Damage

Age range

40 year–90 year

Sex eligibility

All sexes

Study type

Observational

Primary location

vascular surgery department of PUMCH

Beijing, Beijing Municipality, 100730, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

-All patients enrolled had at least ≥70% unilateral or bilateral stenosis of Internal -Carotid Artery， or those who had a <70% stenosis but obvious cerebral ischema symptoms had been existed.

Exclusion criteria

  • Exclusion criteria included poor temporal window
  • Refused to cooperate with us
  • Nonatheromatous such as takayasu arteritis and fibromuscular dysplasia.

Treatment and study plan

vein blood collection

Procedure

5 ml peripheral vein blood samples were collected from each patient admitted to our study at the following time-points：Pre-operative（morning of surgery），just before declamping，30mins after declamping and post-operative（12h）.

Primary outcomes

  1. postoperative ischemic stroke

    Time frame: 7 days after surgery

Secondary outcomes

  1. postoperative elevation of plasma MMP9

    Time frame: perioperative phage

Sponsors and collaborators

Lead sponsor

Peking Union Medical College Hospital

Other

Registry information

Official study title

Dynamic Changes of MMP9 Concentration Cross Carotid Endarterectomy Monitoring Particulate Cerebral Embolisation

Acronym: MMP9MPCE

Important dates

Study start
2012
Primary completion
2013
Study completion
2013
First posted
Apr 9, 2014
Registry last updated
Apr 9, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.