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NCT Number: NCT07227844

Mixed-Reality Visual Attention Task for Neglect Diagnosis and Rehabilitation

Neglect, a common and disabling neurological deficit post-CNS injury, profoundly hinders recovery and escalates healthcare costs. Current diagnostic tools are often insensitive or impractical, and while therapies exist, a significant research gap remains. Traditional methods, including standardized scales and paper-pencil tests, lack precision; even advanced video oculography is limited by cost and accessibility. Rehabilitative approaches like visual scanning and prism adaptation offer some benefit, but more effective solutions are needed. This project utilizes a non-invasive neuromodulatory training approach via a mixed-reality visual attention task delivered through a virtual reality headset. This system aims to improve both neglect diagnosis and personalized therapeutic intervention. The study will assess the headset's safety and practicality, its capacity to detect and lateralize neglect, and its long-term effect on improving attention to the neglected field. By measuring reaction times to visual stimuli within the VR environment, the research seeks to develop a more accessible and impactful tool for both assessing and treating neglect, potentially enabling self-directed therapy and enhancing patient outcomes.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • The study will involve patients over the age of 18 who have been diagnosed with a neurological injury that includes: ischemic stroke, hemorrhagic stroke, tumor, or trauma.
  • Neurological injury that localizes to only one side of the brain
  • At least one hand that retains dexterity enough to use a controller to extinguish the visual stimulus.
  • Cognitive ability to understand simple instructions on how to use the device
  • Visual fields intact

Exclusion criteria

  • Bilateral symptomatic injury
  • Inability to consent or to comply with study
  • Blindness or severe visual deficits other than neglect

Treatment and study plan

VR Neglect Training

Device

VR Neglect Training

Primary outcomes

  1. Improvement in Neglect

    Time frame: 6 months

    Measured as improvement in percentage of lines detected at each location in the VR app

Secondary outcomes

  1. Feasibility/Usage, sessions

    Time frame: 6 months

    Number of sessions completed by each participant

  2. Feasibility/Usage, time

    Time frame: 6 months

    Total time spent using the device

Study contacts

Contact information is provided by the study sponsor or research team.

Markey Olson, PhD

CONTACT

[email protected]

602-406-5944

Sponsors and collaborators

Lead sponsor

Markey Olson

Other

Registry information

Official study title

Pilot Study of a Mixed-Reality Visual Attention Task for Neglect Diagnosis and Rehabilitation

Acronym: Neglex01

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Nov 13, 2025
Registry last updated
Nov 13, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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