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Completed

NCT Number: NCT03344744

miRNA Profile in Aneurysmal Subarachnoid Haemorrhage

The investigators aim to investigate and understand the circulating miRNA profiles after acute aneurysmal subarachnoid haemorrhage and underlying pathological significance.

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Key information

Conditions

Subarachnoid Hemorrhage Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Hemorrhage Intracranial Hemorrhages Nervous System Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Vascular Diseases

Age range

21 year–75 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Department of Surgery, The Chinese University of Hong Kong

Hong Kong, China

About this study

  • The investigators aim to investigate the miRNA classifier for delayed cerebral infarction after aneurysmal subarachnoid haemorrhage;
  • The investigators aim to investigate the corresponding circulating and CSF miRNA profiles.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Aneurysmal subarachnoid hemorrhage patients within the first 72 hours or Healthy volunteers

Exclusion criteria

Previous neurological diseases such as stroke or dementia

Treatment and study plan

Primary outcomes

  1. Circulating micro RNA concentrations

    Time frame: Day 3

    Serum micro RNA concentrations

Secondary outcomes

  1. Circulating micro RNA change

    Time frame: Days 1,2,3,7

    Changes of serum micro RNA concentrations between days 1,2,3,7

  2. Cerebrospinal fluid micro RNA concentrations

    Time frame: Day 1,2,3,7

    Cerebrospinal fluid micro RNA concentrations

  3. Cerebrospinal fluid micro RNA change

    Time frame: Days 1,2,3,7

    Changes of cerebrospinal fluid micro RNA concentrations between days 1,2,3,7

Sponsors and collaborators

Lead sponsor

Chinese University of Hong Kong

Other

Registry information

Official study title

Circulating and CSF miRNA Profile in Patients With Acute Aneurysmal Subarachnoid Haemorrhage

Acronym: miRNA

Important dates

Study start
2017
Primary completion
2023
Study completion
2023
First posted
Nov 17, 2017
Registry last updated
Sep 7, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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