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OpenTrials
Completed

NCT Number: NCT02051296

Minocycline to Reduce Pain After Carpal Tunnel Release

The investigators are looking at whether peri-operative minocycline will reduce the duration of pain after minor hand surgery: carpal tunnel release and trigger finger release.

The investigators' hypothesis is that minocycline will reduce post-operative pain.

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Key information

Conditions

Chronic Pain Neurologic Manifestations Pain Pain, Postoperative Pathologic Processes Pathological Conditions, Signs and Symptoms Post-operative Pain Postoperative Complications Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2

Primary location

Palo Alto VA

Palo Alto, California, 94304, United States

About this study

This is a double blinded randomized controlled trial. Patients are given 100mg of minocycline 2 hours prior to their procedure and then 100mg two times a day for 5 days. The subjects are then contacted daily to check their level of pain. The investigators' outcome of interest is time to pain resolution.

The investigators will perform a futility analysis to assess if a larger trial would be a reasonable next step after this pilot study.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult, Veteran,

Exclusion criteria

  • Kidney failure, Liver failure, thrombocytopenia, ALS, SLE, Frailty, unable to understand survery

Treatment and study plan

Minocycline

Drug

RCT blinded placebo trial

Other names: Minocycline Hydrochloride

Placebo

Drug

RCT blinded placebo trial

Primary outcomes

  1. Time to Pain Resolution

    Time frame: up to 365 days

    the time until patient answers no pain at surgical site for three consecutive days

Sponsors and collaborators

Lead sponsor

VA Palo Alto Health Care System

Fed

Collaborators

  • Stanford University

Registry information

Official study title

A Trial of Minocycline for Pain After Carpal Tunnel and Trigger Release

Important dates

Study start
2012
Primary completion
2014
Study completion
2014
First posted
Jan 31, 2014
Registry last updated
Jun 11, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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