Miniscrew Stability and Peri-implant Inflammation When Precoated K21 vs Ethanol Control

The study design is a split mouth study where 2 miniscrews, one pretreated with K21 the other pretreated (experimental) with ethanol (placebo) are placed in the mouth for orthodontic therapy. All participants will receive 2 or more orthodontic miniscrews with equal numbers of experimental and control pretreatment solutions. Mobility will be assessed at the 4 and 8 week follow up appointments by gentle manipulation with cotton pliers. Clinical success will be defined as maintenance of stability for a period of 8 weeks. Peri-implant inflammation will be assessed at follow up appointments by looking for signs of soft-tissue inflammation (redness, swelling) where possible.

Inclusion criteria

• Good general health, with no significant medical findings
• Requiring at least two miniscrews in their treatment plans (i.e., most participants will have two miniscrews, but some may receive four or six as indicated by their individual treatment plan)
• Miniscrew pairs indicated with comparable anatomical positions and comparable mechanics (direct vs. indirect anchorage).

Exclusion criteria

• Recent or ongoing use of antiresorptive pharmacological agents contraindicating the use of orthodontic miniscrews
• Less than 12 years of age
• Heavy tobacco use (>10 cigarettes/day)
• Peri-implant tissues must be observable at follow-up appointments
• Being unable or unwilling to consent to the study