Mining the Gut Microbiota of Adults for… | Clinical Trial

Key information

Conditions

Adult

Age range

30 year–95 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Zhujiang Hospital of Southern Medical University

Guangzhou, Guangdong, 510000, China

About this study

This study is a community-based, observational cross-sectional investigation, enrolling 1,530 middle-aged and elderly volunteers.

Data were collected through a systematic, multi-dimensional assessment, which included:

Biospecimen Collection: Blood, urine, and stool samples were obtained from the volunteers.

Physical and Imaging Examinations: Procedures included anthropometric measurements, vital sign monitoring, oral examinations, electrocardiograms, physical examinations of key organs, and abdominal ultrasonography.

Psychological and Cognitive Assessments: Standardized scales were administered to assess anxiety/depression and memory function.

All clinical and questionnaire data were processed through standardized procedures, forming a comprehensive health database for subsequent analysis.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

：

Community-dwelling adults aged 30 to 95 years.
Individuals who underwent an annual health examination at the Health Management Center of Huzhou Central Hospital during the specified time period.
Ability to comprehend the study content and voluntarily provide signed informed consent.
Willingness and ability to provide the required biospecimens (blood, urine, stool).

Exclusion criteria

Concurrent participation in another interventional clinical trial that is likely to interfere with the results of this study.
Voluntary withdrawal from the study.

Treatment and study plan

Observational, non-interventional study.

Other

Observational, non-interventional study.

Primary outcomes

Identification of Health-Relevant Signatures in Adults

Time frame: Baseline

Primary Outcome Measure 1)Change in standard laboratory parameters from baseline:Changes in routine laboratory parameters measured in blood, urine, and stool samples, including complete blood count and standard serum biochemistry panels.Unit of Measure: Various laboratory units (e.g., g/L, U/L, mmol/L); 2) Change in anthropometric measurements from baseline: Anthropometric measurements including body weight (kg), height (m), and body mass index (BMI, kg/m²).Unit of Measure:kg, m, kg/m²; 3) Alcohol consumption status: Alcohol consumption status assessed by self- report, categorized as current drinker or non-drinker at enrollment.Unit of Measure:Categorical (yes/no); 4) Hospital Anxiety and Depression Scale (HADS) scores: Anxiety and depression symptom severity assessed using the Hospital Anxiety and Depression Scale, including anxiety and depression subscale scores.Unit of Measure:Score on a standardized scale.

Sponsors and collaborators

Lead sponsor

Zhujiang Hospital

Other

Collaborators

Huzhou Central Hospital

Registry information

Official study title

Identification of Gut Microbiota Signatures Associated With Health Metrics in a Community-based Adult Cohort: a Cross-sectional Study

Important dates

Study start: 2021
Primary completion: 2021
Study completion: 2021
First posted: Jan 15, 2026
Registry last updated: Jan 15, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed