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NCT Number: NCT07722390

Minimally Invasive Non Surgical Treatment Using Injectable Platelet Concentrate in Treatment of Deep Pockets.

The purpose of this study is to evaluate change in pocket depth following using minimally invasive non surgical combined with injectable platelet concentrate .

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Key information

Conditions

Intrabony Periodontal Defects

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Cairo University

Cairo, Egypt

Location status: Recruiting

Location contact

Faculty of dentistry Cairo university

CONTACT

[email protected]

+01002159535

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with periodontitis stage III-IV.
  • Presence of at least one intrabony defect with radiographic component ≥ 3mm deep and PPD≥ 6mm (not affecting a tooth with 'hopeless' prognosis).
  • Patients willing to sign informed consent and to be in the study until the 6-months follow-up.
  • Full-mouth plaque score <30% following step 1 periodontal therapy

Exclusion criteria

  • Smoker/vaper (currently or in past 5 years).
  • Contributory medical history (e.g. cardiovascular disease, diabetes, psychiatric conditions).

Treatment and study plan

Injectable PRF

Biological

I-PRF will be prepared from 10 mL of autologous venous blood and injected into the cleaned defect, followed by placement of a custom-made transparent vacuum-formed stent for 15 minutes to prolong local contact

MINST

Procedure

Participants will receive minimally invasive non-surgical periodontal therapy (MINST) alone using P3 Woodpecker piezoelectric scaler for the selected periodontal intrabony defect

Primary outcomes

  1. Change in pocket depth

    Time frame: 6 months

    Baseline measurements will be taken at the first visit. Probing depth will be measured at six sites per tooth (mesiobuccal, midbuccal, distobuccal, mesiolingual, midlingual, distolingual) using a UNC-15 periodontal probe

Secondary outcomes

  1. Pocket closure

    Time frame: 6 months from baseline

    Pocket depth of less than or equal 4 millimeters with no bleeding on probing at 6-month follow-up. PD will be measured from the gingival margin to the base of the pocket at six sites per tooth using a UNC-15 periodontal probe. PD reduction will be calculated by subtracting the 6-month PD from baseline PD

  2. Clinical attachment gain

    Time frame: 6 months from baseline

    CAL will be measured from the cementoenamel junction (CEJ) to the base of the pocket at the same six sites using a UNC-15 periodontal probe. CAL gain will be calculated by subtracting follow-up CAL (6 months) from baseline CAL

  3. Radiographic defect reduction:

    Time frame: 6 months

    Periapical radiographs of selected study sites will be taken at baseline and at 6 months using the parallel technique with Rinn holders. Each participating practice used the same setting and exposure time for radiographs taken at both visits to standardize positioning and minimize distortion of sequential radiographs

  4. Patient reported outcomes

    Time frame: 6 months

    To evaluate patient perceptions about the performed procedure and post-therapy period. The extent of discomfort and/or pain experienced will be evaluated using a horizontal visual analog scale (VAS).

Study contacts

Contact information is provided by the study sponsor or research team.

Hania Haggag

CONTACT

[email protected]

+01210239417

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Official study title

THE EFFECT OF ADJUNCTIVE I-PRF ON THE OUTCOMES OF MINIMALLY-INVASIVE NON-SURGICAL THERAPY OF PERIODONTAL INTRABONY DEFECTS: A RANDOMIZED CLINICAL TRIAL

Important dates

Study start
2025
Primary completion
2027
Study completion
2028
First posted
Jul 23, 2026
Registry last updated
Jul 23, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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