Skip to main content
OpenTrials
Completed

NCT Number: NCT03089710

Mini-fluid Challenge in Predicting Fluid Responsiveness During Prone Position Spine Surgery

Perioperative fluid management is crucial for patients' outcome. Muller et al developed a "Mini-fluid challenge method " to predict fluid responsiveness and the efficacy. The investigators design the study to investigate the effectiveness of mini-fluid challenge test in prone position surgery.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Anesthesia

Age range

20 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

National Taiwan University

Taipei, Taiwan

About this study

Perioperative fluid management is crucial for patients' outcome. Series of studies have indicated that adequate fluid management optimizes the cardiac out put, improves tissue perfusion, thus decrease the risk of postoperative morbidity. Muller et al developed a "Mini-fluid challenge method " to predict fluid responsiveness and the efficacy. To the best of our knowledge, the efficacy of the test was not discussed in the perioperative care in prone position surgery. The investigators design the study to investigate the effectiveness of mini-fluid challenge test in prone position surgery.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

meet both of

  • Patients receiving scheduled prone position spine surgery
  • BMI 18.5~30 kg.m-2

Exclusion criteria

  • age younger then 20 yrs or elder than 80 yrs
  • pregnant women
  • patients in intensive care units
  • patients with the underlying disease including respiratory failure(FEV1/FVC < 70 % and FEV1 < 50%), heart failure(NYHA score =III、IV), kidney failure(eGFR< 60 ml.min-1.1.73m-2), liver failure
  • patients with ongoing infection
  • patients allergic to voluven

Treatment and study plan

Mini-fluid challenge

Other

Mini-fluid challenge test with 100mL colloid infusion in 1 min

Primary outcomes

  1. Change of cardiac index after fluid loading

    Time frame: 3hr

    interpretate the correlation of mini-fluid challenge and conventional fluid challenge

Secondary outcomes

  1. pulse pressure variation(PPV)

    Time frame: 3hr

    interpretate the correlation of PPV and conventional fluid challenge

Other outcomes

  1. stroke volume variation(SVV)

    Time frame: 3hr

    interpretate the correlation of SVV and conventional fluid challenge

  2. plethysmographic variation index(PVI)

    Time frame: 3hr

    interpretate the correlation of PVI and conventional fluid challenge

Sponsors and collaborators

Lead sponsor

National Taiwan University Hospital

Other

Registry information

Official study title

The Effectiveness of Mini-fluid Challenge in Predicting Fluid Responsiveness During Prone Position Spine Surgery

Important dates

Study start
2017
Primary completion
2018
Study completion
2018
First posted
Mar 24, 2017
Registry last updated
Feb 11, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.