Mindfulness-oriented Recovery Enhancement (MORE) for Cancer Pain Relief

The purpose of this study is to evaluate whether or not mindfulness-based interventions/MBIs may help reduce chronic pain in participants who have cancer-related chronic pain. MBIs are therapeutic programs that use mindfulness meditation practices to help people focus on the present moment, as well as encourage acceptance of thoughts, emotions, and body sensations. The researchers think that an MBI treatment called Mindfulness-oriented Recovery Enhancement (MORE) may help people who are experiencing cancer-related chronic pain.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

Chronic Pain Cancer Pain Neurologic Manifestations Pain Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2

Primary location

Memorial Sloan Kettering Cancer Center (All Protocol Activities)

New York, 10065, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

English speaking
Age ≥ 18 years or older
A history of cancer with no restrictions placed on type of cancer
Determined to be either no-evidence of disease or stable oncological disease by referring or study physicians/advanced practice providers
Having a pain (musculoskeletal, generalized, or neuropathic) rating of 4 or greater in worst pain on a 0-10 numerical rating scale in the preceding week
Having had pain for at least 3 months and at least 15 days with pain in the preceding 30 days
Willing to adhere to all study-related procedures, including randomization to one of two treatment arms: MORE or WLC
Ability to attend video-call session and a quiet/private location

Exclusion criteria

Active suicidality or schizophrenia
Plan to initiate palliative radiation or interventional pain procedure within the next 12 weeks
Cognitive impairment preventing completing PRO independently or participate in virtual MORE as evaluated by study clinicians

Treatment and study plan

MORE treatments

Behavioral

MORE participants will also be asked to engage in 15 minutes/day of skill practice at home, and complete daily diaries of mindfulness practice time

Standard of Care for Pain Management

Other

Participants in the WLC group continue to receive their standard medical care and pain management as prescribed by their physicians or other health care providers.

Primary outcomes

Rate of participant enrollment to the study

Time frame: 12 months

Feasibility of the intervention will be determined by Rate of participant enrollment to the study

Sponsors and collaborators

Lead sponsor

Memorial Sloan Kettering Cancer Center

Other

Registry information

Official study title

Adapting Mindfulness-oriented Recovery Enhancement (MORE) for Cancer Pain Relief: The MORE Relief Trial

Important dates

Study start: 2023
Primary completion: 2027
Study completion: 2027
First posted: May 26, 2023
Registry last updated: Sep 23, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed