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Completed

NCT Number: NCT02900326

Mindfulness-based Stress Reduction (MBSR) Program Combined With Endurance Exercise Training: a Help in Treatment for Breast Cancer

Integrative approaches to promote wellness and reduce the distress associated with cancer are considered as essential components of cancer care. In case, exercise training has been shown to produce many positive physiological and psychological benefits. Mindfulness-based stress reduction program shows similar beneficial effects, and especially in emotional distress management. The aim of the study is to examine the cumulative effect of an 8 week-exercise-training program combined with an MBSR program on cardio-respiratory fitness and quality of life in women with breast cancer. These effects are thought to be mediated in part through changes in underlying brain processes, that investigators will be put in light. Through telomerase activity, oxidative stress, mitochondrial respiration and blood cytokine level measurements, investigators could expect to better understand the effect of these combined training in breast cancer.

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Key information

Age range

18 year–65 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Physiologie et EFR/ EA 3072 mitochondrie, stress oxydant et protection musculaire

Strasbourg, 67091, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Breast cancer
  • Having completed the chemotherapy period
  • Undergoing radiotherapy and/or hormono therapy

Exclusion criteria

  • Regular physical activity higher than 4 hours per week.
  • Any disease cardiac, respiratory, neurological or articular disease, which counteract the muscular training )

Treatment and study plan

Endurance exercise training

Other

In each group, there will be a comparison of aerobic capacity, quality of life (with questionnaires), functional cerebral measurements (fRMI), and telomerase activity between before and after the 8 weeks program

Mindfulness-based-stress-reduction

Other

Both interventions together

Other

Vo2max measurements

Other

Telomerase activity on a blood sample

Genetic

Quality of life (questionnaires)

Other

Cerebral IRMf

Other

Primary outcomes

  1. Evolution of V02 max between inclusion and 8 weeks

    Time frame: 8 weeks

    effect of physical training associated with mental work on physical abilities of patients

Sponsors and collaborators

Lead sponsor

University Hospital, Strasbourg, France

Other

Registry information

Official study title

Effect of a Mindfulness-based Stress Reduction (MBSR) Program Combined With Endurance Exercise Training: a Help to Improve Exercise Capacity and Quality of Life in Breast Cancer

Acronym: MBSR

Important dates

Study start
2015
Primary completion
2015
Study completion
2021
First posted
Sep 14, 2016
Registry last updated
Dec 19, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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