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NCT Number: NCT07741825

Mindfulness-based Relapse Prevention for Peer Workers

Adapt and test the effectiveness of MBRP for substance use peer workers compared to a standard of care (referral to 12-step) control condition on substance use, relapse risk, and burnout among peers in a pilot hybrid type 1 trial.

The goal of this clinical trial is to learn if Mindfulness-Based Relapse Prevention can reduce substance use, relapse risk, and burnout among substance use peer workers. The objectives are to:

1. Identify the causes, consequences, and risk and protective factors for relapse among peer workers; 2. Identify peers' preferences related to MBRP content, structure, and delivery; 3. Adapt the MBRP intervention for peer workers; and 4. Assess the preliminary effectiveness and implementation outcomes of the adapted MBRP intervention.

Researchers will compare MBRP to referral to 12-step (standard of care) to see if MRBP works to reduce substance use, relapse risk, and burnout.

Participants will asked to:

* Participate in MBRP (8 weekly 2-hour virtual sessions) * Complete 4 surveys assessing well-being outcomes * Participate in 1 virtual interview about your experience

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Key information

Conditions

Relapse/Recurrence Behavior Behavioral Symptoms Burnout Burnout, Psychological Chemically-Induced Disorders Disease Attributes Mental Disorders Occupational Diseases Occupational Stress Pathologic Processes Pathological Conditions, Signs and Symptoms Recurrence Stress, Psychological Substance Use (Drugs, Alcohol) Substance-Related Disorders

Age range

18 year–100 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Are > 18 years old
  • Fluent in English
  • Be currently employed in a substance use peer support role
  • At-risk for SUD relapse as measured by a craving score of >15 on the adapted Penn Alcohol Craving Scale

Exclusion criteria

  • Have a cognitive impairment that jeopardizes informed consent
  • Actively suicidal or psychotic

Treatment and study plan

Mindfulness Based Relapse Prevention

Behavioral

MBRP for peer workers consists of 8 weekly 2-hour virtual sessions.

Standard of Care

Behavioral

Referral to 12-step programming

Primary outcomes

  1. Change from baseline in biologically verified substance use at 1, 3, and 6 months as measured by Saliva Drug Assays

    Time frame: From enrollment to 6 months

    Saliva drug assays detecting the presence or absence of commonly used substances. Results are reported as positive or negative for each substance tested, with negative results indicating a better outcome.

  2. Change from baseline in self-reported substance use days at 1, 3, and 6 months as measured by the Timeline Follow-Back (TLFB)

    Time frame: From enrollment to 6 months

    A calendar-based interview assessing daily substance use over a specified recall period. Outcomes are reported as the number of days of substance use during the assessment period, with fewer days indicating a better outcome.

  3. Change from baseline in relapse warning Signs at 1, 3, and 6 months as measured by the Advance Warning of Relapse (AWARE) Questionnaire

    Time frame: From enrollment to 6 months

    A 28-item; 7-point Likert-type scale assessing warning signs associated with relapse risk. Total scores range from 28 to 196, with higher scores indicating greater relapse risk (worse outcome).

  4. Change from baseline in professional quality of life at 1, 3, and 6 months as measured by the Professional Quality of Life Scale (ProQOL)

    Time frame: From enrollment to 6 months

    A 30-item; 5-point Likert-type scale assessing professional quality of life across three 10-item subscales: Compassion Satisfaction, Burnout, and Secondary Traumatic Stress. Each subscale score ranges from 10 to 50. Higher Compassion Satisfaction scores indicate a better outcome, whereas higher Burnout and Secondary Traumatic Stress scores indicate worse outcomes.

  5. Post-intervention perceived feasibility of the intervention as measured by the Feasibility of Intervention Measure (FIM)

    Time frame: Immediately after the final intervention session

    A 4-item; 5-point Likert-type scale assessing the perceived feasibility of an intervention. Total scores range from 4 to 20, with higher scores indicating greater perceived feasibility (better outcome).

  6. Post-intervention perceived acceptability of the intervention as measured by the Acceptability of Intervention Measure (AIM)

    Time frame: Immediately after the final intervention session

    A 4-item; 5-point Likert-type scale assessing the perceived acceptability of an intervention. Total scores range from 4 to 20, with higher scores indicating greater perceived acceptability (better outcome).

Secondary outcomes

  1. Change from baseline in the coping score assessed by the Brief-COPE measure at 6 months

    Time frame: From enrollment to 6 months

    A 28-item; 4-point Likert-type scale assessing coping strategies. The Brief COPE consists of 14 two-item subscales, each ranging from 2 to 8, with higher scores indicating greater use of that specific coping strategy. There is no overall total score.

  2. Change from baseline in total score of emotion regulation assessed by the Difficulty in Emotion Regulation Scale (DERS) measure at 6 months

    Time frame: From enrollment to 6 months

    A 36-item; 5-point Likert-type scale assessing difficulties with emotion regulation. Total scores range from 36 to 180, with higher scores indicating greater difficulties in emotion regulation (worse outcome).

  3. Change from baseline in total score of perceived stress assessed by the Perceived Stress Scale (PSS-10) measure at 6 months

    Time frame: From enrollment to 6 months

    A 10-item; 5-point Likert-type scale assessing perceived stress. Total scores range from 0 to 40, with higher scores indicating greater perceived stress (worse outcome).

  4. Change from baseline in total score of trait mindfulness assessed by the Five Factor Mindfulness Questionnaire (FFMQ-15) measure at 6 months

    Time frame: From enrollment to 6 months

    A 15-item; 5-point Likert-type scale assessing trait mindfulness. Total scores range from 15 to 75, with higher scores indicating greater mindfulness (better outcome).

  5. Change from baseline in total score of acceptance assessed by the Acceptance and Action Questionnaire-II (AAQ-II) measure at 6 months

    Time frame: From enrollment to 6 months

    A 7-item; 7-point Likert-type scale assessing psychological inflexibility/experiential avoidance. Total scores range from 7 to 49, with higher scores indicating greater psychological inflexibility and experiential avoidance (worse outcome).

Other outcomes

  1. Change from baseline in mean score of mental health assessed by the Behavior and Symptom Identification Scale (BASIS-24) measure at 6 months

    Time frame: From enrollment to 6 months

    A 24-item; 5-point Likert-type scale assessing mental health symptoms and functioning. Total scores range from 0 to 4 (calculated as the mean of completed items), with higher scores indicating greater psychiatric symptoms and functional difficulties (worse outcome).

  2. Change from baseline in mean score of recovery capital assessed by the Multidimensional Inventory of Recovery Capital (MIRC) measure at 6 months

    Time frame: From enrollment to 6 months

    A 28-item; 4-point Likert-type scale assessing recovery capital across multiple domains. Total scores range from 28 to 112, with higher scores indicating greater recovery capital (better outcome).

  3. Change from baseline in mean score of work engagement assessed by the Utrecht Work Engagement Scale (UWES-9) measure at 6 months

    Time frame: From enrollment to 6 months

    A 9-item; 7-point Likert-type scale assessing work engagement. Total scores range from 0 to 54 (or a mean score ranging from 0 to 6), with higher scores indicating greater work engagement (better outcome).

Study contacts

Contact information is provided by the study sponsor or research team.

Katie A McCormick, PhD, MSW

CONTACT

[email protected]

(512) 471-5457

Sponsors and collaborators

Lead sponsor

University of Texas at Austin

Other

Registry information

Official study title

Adapting and Pilot Testing Mindfulness-Based Relapse Prevention for Substance Use Peer Workers

Acronym: MBRP

Important dates

Study start
2026
Primary completion
2030
Study completion
2030
First posted
Aug 3, 2026
Registry last updated
Aug 3, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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