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Completed

NCT Number: NCT02059200

Mindfulness Based Compassionate Living in Recurrent Depression

Since a few years, Mindfulness Based Cognitive Therapy (MBCT) has been used as treatment for patients suffering from recurrent depression. Though a number of studies show that MBCT is effective in this population and MBCT reduces the chances of relapse/recurrence in recurrent depressive patients, the chance of a new depression developing after end of treatment is still considerable. Ergo, there is room for improvement.

Especially the development of a non-judging or compassionate attitude towards all experience seems to mediate the treatment effect. It is therefore our expectation that a follow-up intervention that focuses specifically on self-compassion could prove very useful in elaborating on the effects of MBCT.

The research question of this research is therefore: what is the effect of compassion training in people suffering from recurrent depression who have already received MBCT training?

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Key information

Conditions

Recurrent Depression Behavior Behavioral Symptoms Depression

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University Medical Center Nijmegen

Nijmegen, Gelderland, Netherlands

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Recurrent depression according to the DSM-IV criteria.
  • Having participated in an MBCT training (>= 4 sessions)

Exclusion criteria

  • One or more previous (hypo)manic episodes according to DSM-IV criteria.
  • Primary psychotic disorder, e.g. schizophrenia or delusions.
  • Clinically relevant neurological conditions (e.g. brain trauma or dementia) or somatic conditions (e.g. cancer, AIDS) that could be related to the depression.
  • Current alcohol and/or drug abuse.
  • Use of high dosages of benzodiazepines.
  • Recent electro convulsive therapy (ECT) (less than 3 months ago).
  • Problems impeding participating in a group, such as severe borderline personality disorder.
  • No prior experience with MBCT.
  • Problems impeding completing the questionnaires, such as cognitive dysfunctions (only assessed if suspected).
  • Subnormal intelligence (IQ < 80) (only assessed if suspected).

Treatment and study plan

Mindfulness Based Compassionate Living

Behavioral

The MBCL program consists of eight biweekly group sessions of 2.5 hours, in which the participants get formal meditation exercises, some theoretical information and participate in inquiry on the meditation exercises and homework assignments. Homework assignments are given after every session, consisting of formal and informal meditation exercises primarily and some diary instructions.

Other names: MBCL, Mindfulness Based Compassion Training

Primary outcomes

  1. Beck Depression Inventory-II

    Time frame: 1 year

    The BDI-II measures depression symptoms. Measurements will be taken at baseline, end of treatment/control and follow up.

Secondary outcomes

  1. Self-Compassion Scale

    Time frame: 1 year

    The Self-Compassion Scale measures Self-Compassion. Measurements will be taken at baseline, end of treatment/control and follow-up.

  2. Five Facet Mindfulness Questionnaire

    Time frame: 1 year

    The FFMQ measures mindfulness skills. Measurements will be taken at baseline, end of treatment/control and follow-up.

  3. The Acceptance and Action Questionnaire-II

    Time frame: 1 year

    The AAQ-II measures Experiential Avoidance. Measurements will be taken at baseline, end of treatment/control and follow-up.

  4. Fears of Compassion Scale (3)

    Time frame: 1 year

    The FoCS (3) measures fear of Self-Compassion. Measurements will be taken at baseline, end of treatment/control and follow-up.

  5. Types of Positive Affect Scale

    Time frame: 1 year

    The TPAS measures Positive Affect. Measurements will be taken at baseline, end of treatment/control and follow-up.

  6. The World Health Organization Quality of Life Scale

    Time frame: 1 year

    The WHO-QoL measures Quality of Life. Measurements will be taken at baseline, end of treatment/control and follow-up.

  7. The Ruminative Response Scale

    Time frame: 1 year

    The RRS measures Rumination. Measurements will be taken at baseline, end of treatment/control and follow-up.

  8. The Childhood Trauma Questionnaire

    Time frame: Baseline

    The CTQ measures Childhood Adversity. Measurements will be taken at baseline only.

Sponsors and collaborators

Lead sponsor

Radboud University Medical Center

Other

Collaborators

  • Triodos Foundation

Registry information

Official study title

The Effectiveness of Mindfulness Based Compassionate Living in Recurrent Depression

Acronym: MBCL-RD

Important dates

Study start
2013
Primary completion
2015
Study completion
2015
First posted
Feb 11, 2014
Registry last updated
Apr 18, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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