Midkine Role With Deregulated Oxidative and Immune Milieu in Induction of Preeclampsia

Preeclampsia (PE) is a hypertensive pregnancy-related disorder that endangers maternal and fetal outcomes and accounts for 9-10% of maternal mortalities with its early-onset phenotype is the most dangerous, but its etiology is still not fully elucidated.

Midkine (MDK) is a multifunctional protein that plays a unique role in the development of hypertension (HTN), via its proatherogenic effect and induction of overexpression of angiotensin converting enzyme. Oxidative stress (OS) upregulates the expression of MDK and MDK induces propagation of neoangiogenesis and acts as chemotactic for neutrophils.

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Key information

Conditions

Pre-eclampsia Female Urogenital Diseases and Pregnancy Complications Hypertension, Pregnancy-Induced Pregnancy Complications Urogenital Diseases

Age range

21 year–50 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Banha University

Banhā, El- Qalyobia, 13511, Egypt

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Newly pregnant normotensive (NT) women with singleton fetus;
Free of the Exclusion Criteria.

Exclusion criteria

Women with history of complicated pregnancy;
Had manifest essential hypertension, Diabetes Mellitus or chronic kidney diseases;
Had multiple gestational sacs, morbid obesity with Body Mass Index at time of pregnancy diagnosis over 35 kg/m2;
Had genetic disorders, coagulopathy, autoimmune diseases or maintained on immunosuppressive therapy.

Treatment and study plan

ELISA

Diagnostic Test

ELISA estimation of serum Midkine, tumor necrosis factor Alfa, superoxide dismutase, malondialdehyde, placental growth factor and placental soluble fms-like tyrosine kinase 1

Primary outcomes

Severity of Pre-Eclampsia (PE)

Time frame: 8 months

Correlation between Serum midkine levels and blood pressure measurements

Sponsors and collaborators

Lead sponsor

Benha University

Other

Registry information

Official study title

Midkine Interplays With Oxidative Stress and Inflammatory Milieu to Induce Preeclampsia in Normotensive Pregnant Women

Important dates

Study start: 2023
Primary completion: 2023
Study completion: 2023
First posted: Mar 25, 2024
Registry last updated: Mar 26, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed