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Completed

NCT Number: NCT06005064

Middle Age muScle Krill Study

This study will determine the effect of 6 months of supplementation with krill oil on muscle strength and mass in middle-aged adults. The study hypothesis is that krill oil supplementation will increase muscle strength and mass in middle-aged adults.

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Key information

Conditions

Sarcopenia Atrophy Muscular Atrophy Nervous System Diseases Neurologic Manifestations Neuromuscular Manifestations Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

35 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Glasgow

Glasgow, United Kingdom

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Be 35-60 years old
  • Have a BMI of less than 35kg/m2

Exclusion criteria

  • People with diabetes, severe cardiovascular disease, seizure disorders, uncontrolled hypertension (>150/90mmHg at baseline measurement), cancer or cancer that has been in remission <5 years, ambulatory impairments which would limit the ability to perform assessments of muscle function, dementia, on anticoagulant therapy, and/or taking medication known to affect muscle (e.g., steroids).
  • People who have allergies to seafood, and/or regular consumption of more than 1 portion of oily fish per week.
  • People who perform regular (>1 day/week) resistance exercise training.

Treatment and study plan

Krill oil

Dietary Supplement

Superba krill oil

Vegetable oil

Dietary Supplement

Mixed vegetable oil

Primary outcomes

  1. Change in knee extensor maximal isometric torque ( MVC)

    Time frame: Change from baseline to 24 weeks

    Knee extensor maximal isometric torque measured during a maximal voluntary contraction

Secondary outcomes

  1. Change in fat mass

    Time frame: Change from baseline to 24 weeks

    Whole body fat mass measured by measured via bio-electrical impedance

  2. Change in lean mass

    Time frame: Change from baseline to 24 weeks

    Whole body lean mass measured by measured via bio-electrical impedance

  3. Change in omega-3 levels

    Time frame: Change from baseline to 24 weeks

    Red blood cell omega-3 levels

  4. Change in Grip strength

    Time frame: Change from baseline to 24 weeks

    Grip strength measured with a hand held dynamometer

  5. Change in Muscle thickness

    Time frame: Change from baseline to 24 weeks

    Vastus lateralis muscle thickness measured by ultrasound

Other outcomes

  1. Change in systemic inflammation

    Time frame: Change from baseline to 24 weeks

    Plasma levels of C-reactive protein, IL-1, IL-6, IL-8, IL-10, and TNF-α

  2. Change in muscle inflammation

    Time frame: Change from baseline to 24 weeks

    Muscle total protein levels of TNF-α, IL-1β, IL-6, IL-8, MCP-1 and total and phosphorylated levels of NFκB, JNK1/2 and STAT3

  3. Change in muscle anabolic signalling

    Time frame: Change from baseline to 24 weeks

    Muscle total and phosphorylated protein levels of mTOR, IRS-1, Akt, 4EBP-1, p70S6K, RPS6, FOXO-1, GSK3β and total protein levels of MAFBx and MURF-1

Sponsors and collaborators

Lead sponsor

University of Glasgow

Other

Registry information

Official study title

The Effect of Krill Oil Supplementation on Muscle Function and Mass in Middle-aged Adults: A Randomised Controlled Trial

Acronym: MASK

Important dates

Study start
2023
Primary completion
2025
Study completion
2025
First posted
Aug 22, 2023
Registry last updated
Apr 29, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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