Microvascular Cardiac Allograft Vasculopathy Trial

Inclusion criteria

• able to consent
• Written consent of the participant after clarification and sufficient time to think about participation
• heart transplant recipient
• Indication for routine invasive diagnostics or due to symptoms
• Exercise tolerant in everyday life - cycling, climbing stairs at least 2 floors at a moderate speed without symptoms of exertion or dyspnea

Exclusion criteria

• Addiction or other diseases that do not allow the patient to assess the nature and scope as well as possible consequences of the study
• Patients or their legal guardians who do not sign the declaration of consent or who cannot fully understand it due to a lack of German language skills
• Pregnant women, breastfeeding women
• Severe comorbidities affecting the miRNA profile: diabetes mellitus, malignancy, end-stage renal disease with renal replacement therapy
• Contraindication to the stress test: signs of cardiac decompensation, angina pectoris, dyspnea, hyperthyroidism, GFR <30 ml/min, peripheral arterial disease, pheochromocytoma, angle-closure glaucoma, prostate adenoma, paroxysmal tachycardia, tachycardia atrial fibrillation
• Evidence of an acute rejection or local wall motion disturbances in the resting echocardiography