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Completed

NCT Number: NCT03089242

MicroRNAs in Acute Kidney Injury

Profiling of microRNAs and long noncoding RNAs (lncRNAs) in patients undergoing cardiac surgery. Analysis: Prediction of acute kidney injury by plasma expression profile of microRNAs?

Completed

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Key information

Conditions

Kidney Injury in Cardiac Surgery - Expression of microRNAs

Age range

18 year–90 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Klinik für Anästhesiologie

Düsseldorf, 40225, Germany

About this study

In this pilot study we will include 150 patients undergoing cardiac surgery in a German university hospital. We will profile microRNA expression in plasma and urine before and at several timepoints after surgery. We will use a preselected panel of microRNAs and lncRNAs for analysis. Goal is to identify microRNAs/lncRNAs that are able to predict the occurence of AKI in these patients.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • cardiac surgery

Exclusion criteria

  • preexisting chronic kidney injury
  • inclusion in another study
  • pregnancy
  • Kidney transplantation in history
  • GFR < 30 ml/min (glomerular filtration rate)
  • ECLS therapy (extracorporal life support)

Treatment and study plan

observation of microRNA expression

Other

no intervention

Primary outcomes

  1. acute kidney injury

    Time frame: 1 year

    AKI Stadium II or III following cardiac surgery.

Sponsors and collaborators

Lead sponsor

Heinrich-Heine University, Duesseldorf

Other

Registry information

Official study title

MicroRNAs in Acute Kidney Injury (MIRAKI) - a Pilotstudy -

Acronym: MIRAKI

Important dates

Study start
2017
Primary completion
2018
Study completion
2018
First posted
Mar 24, 2017
Registry last updated
May 7, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.