Microplastics in Paraneoplastic and Intratumoral for Colorectal Cancer

The objective of this study is to identify and characterize microplastics present in peritumoral and intratumoral tissues of colorectal cancer patients, and to investigate their associations with gut microbiome composition and metabolic profiles. By integrating microplastic analysis with metagenomic and metabolomic data, we aim to explore the potential impact of environmental microplastic exposure on tumor microenvironment alterations, microbial dysbiosis, and metabolic reprogramming in colorectal cancer.

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Key information

Conditions

Colorectal Cancer (MSI-H) Colonic Diseases Colorectal Neoplasms Digestive System Diseases Digestive System Neoplasms Gastrointestinal Diseases Gastrointestinal Neoplasms Intestinal Diseases Intestinal Neoplasms Microplastic Exposure Neoplasms Neoplasms by Site Rectal Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

The First Affiliated Hospital of Chongqing Medical University

Chongqing, Chongqing Municipality, 400016, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Adult patients (≥18 years old) with histologically confirmed colorectal adenocarcinoma.
Undergoing elective radical colorectal cancer resection at the study hospital.
No prior chemotherapy, radiotherapy, or targeted therapy before surgery.
Availability of both tumor tissue and adjacent normal (peritumoral) tissue samples during surgery.
Willingness to provide stool and/or blood samples for metagenomic and metabolomic analysis.
Ability to understand the study procedures and provide written informed consent.

Exclusion criteria

Patients with a history of other malignancies within the past 5 years.
Emergency surgery due to obstruction, perforation, or bleeding.
Inadequate sample quality or volume for microplastic, metagenomic, or metabolomic analysis.
Presence of chronic inflammatory bowel disease (e.g., Crohn's disease or ulcerative colitis).
Use of antibiotics, probiotics, or prebiotics within 4 weeks prior to sample collection.
Pregnant or breastfeeding women.
Refusal or inability to provide informed consent.

Treatment and study plan

exposure to microplastic

Other

Microplastic content in cancerous and paracancerous tissues

Primary outcomes

genomics

Time frame: Blood specimens were obtained within one week prior to surgery.

Genomics was tested by preoperative blood specimens.

Secondary outcomes

metabolomics

Time frame: Blood specimens were obtained within one week prior to surgery.

Metabolomics was tested by preoperative blood specimens.

Sponsors and collaborators

Lead sponsor

Dong Peng

Other

Registry information

Official study title

Identification of Paraneoplastic and Intratumoral Microplastics in Colorectal Cancer and Their Association Analysis With Macrogenomics and Metabolomics

Important dates

Study start: 2024
Primary completion: 2026
Study completion: 2026
First posted: Jul 14, 2025
Registry last updated: Jul 14, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

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