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NCT Number: NCT07141238

Microplastic Analysis in Pediatric Inflammatory Bowel Disease

The goal of this observational study is to measure and compare the presence of microplastics in children with inflammatory bowel disease (IBD) and children without IBD. The main questions it aims to answer are:

Are microplastics detectable in different biological samples from children? Are there differences in microplastic burden between children with and without IBD?

Researchers will collect biological samples including: intestinal tissue (from routine endoscopy), stool, urine, blood.

Raman spectroscopy will be used to detect and characterize microplastics in each sample type. Participants will not receive any medication or intervention as part of this study. All samples will be collected during standard clinical procedures.

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Key information

Conditions

Crohn Disease Colitis Colitis, Ulcerative Colonic Diseases Digestive System Diseases Gastroenteritis Gastrointestinal Diseases Inflammatory Bowel Disease (IBD) Inflammatory Bowel Diseases Intestinal Diseases Pediatric Inflammatory Bowel Diseases Ulcerative Colitis (UC)

Age range

Up to 18 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Medical University of Gdańsk, Department of Pediatrics, Gastroenterology, Allergolgy and Nutrition

Gdansk, 80-803, Poland

Location status: Recruiting

Location contact

Dominika Marszk, MD

CONTACT

[email protected]

609619101

Michał Brzeziński, Professor

CONTACT

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age <18 years
  • Undergoing clinically indicated gastrointestinal endoscopy
  • For IBD group: confirmed diagnosis of Crohn's disease or ulcerative colitis
  • For control group: no current or past diagnosis of IBD

Exclusion criteria

  • Age 18 years or older
  • Lack of informed consent from legal guardian
  • Lack of written assent from the participant if age ≥13 years

Treatment and study plan

Environmental microplastic exposure

Other

Exposure to environmental microplastics measured by their presence in intestinal tissue, blood, urine, and stool using Raman spectroscopy. This study does not assign any exposure or treatment; it investigates the existing presence of microplastics as an environmental factor of interest.

Primary outcomes

  1. Presence and concentration of microplastics in intestinal tissue samples

    Time frame: Day of endoscopy (Baseline)

    Quantification of microplastics (number of particles per gram of tissue) detected using Raman spectroscopy in intestinal mucosal biopsies collected during clinically indicated endoscopy.

Secondary outcomes

  1. Comparison of microplastic burden between children with IBD and controls

    Time frame: Baseline (Day of sample collection)

    Assessment of differences in all biological matrices (tissue, stool, blood, urine) between children with inflammatory bowel disease and controls

Study contacts

Contact information is provided by the study sponsor or research team.

Dominika Marszk, MD

CONTACT

[email protected]

+48609619101

Sponsors and collaborators

Lead sponsor

Medical University of Gdansk

Other

Registry information

Official study title

Analysis of Microplastics in Pediatric Inflammatory Bowel Disease Using Raman Spectroscopy: A Multi-Matrix Study

Acronym: MAP-IBD

Important dates

Study start
2025
Primary completion
2025
Study completion
2026
First posted
Aug 26, 2025
Registry last updated
Sep 30, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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