Microenvironment of Adipose Tissue in Endocannabinoid System

The purpose of this study is examine the relationship between adipose tissue inflammation and activation of the endocannabinoid system before and after Roux-en-Y gastric bypass surgery. The investigators hypothesize that the metabolic improvements and weight loss are due to mechanisms that antagonize the endocannabinoid system.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Obesity Body Weight Nutrition Disorders Nutritional and Metabolic Diseases Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

20 year–60 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Vanderbilt University Medical Center

Nashville, Tennessee, 37232, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

BMI>35 kg/m2
Age 20-60 yrs
Approved and scheduled for gastric bypass surgery
Stable body weight for past 3 months

Exclusion criteria

Positive pregnancy test
Previous gastric surgeries
Intercurrent infections
History of ketoacidosis or current metabolic acidosis
Serum creatinine or liver function tests > 2 times upper limits of normal
Taking drugs that are known to affect carbohydrate or lipid metabolism other than anti-diabetes mediations.

Sponsors and collaborators

Lead sponsor

Vanderbilt University

Other

Registry information

Official study title

Microenvironment of Adipose Tissue in Endocannabinoid System Before and After Roux-en-y Gastric Bypass Surgery

Important dates

Study start: 2008
Primary completion: 2012
Study completion: 2012
First posted: Sep 16, 2009
Registry last updated: Jun 19, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed