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Completed

NCT Number: NCT01332734

Microcirculatory Changes During Magnesium Sulphate Infusion in Sepsis

During infections (sepsis) bloodflow in small vessels (microcirculation) becomes disturbed. Restoration of bloodpressure and cardiac performance may not be sufficient to correct these alterations. Magnesium is a potent vasodilator which may be used to open up the small vessels, in order to reduce organ failure.

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Key information

Conditions

Severe Sepsis Infections Inflammation Pathologic Processes Pathological Conditions, Signs and Symptoms Sepsis Septic Shock Shock Shock, Septic Systemic Inflammatory Response Syndrome

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Hospital of Lithuanian university of health sciences

Kaunas, LT 44307, Lithuania

About this study

In a single-center open label study we evaluated the effects of magnesium sulphate (MgS) infusion on the sublingual microcirculation perfusion in fluid resuscitated patients with severe sepsis and septic shock within the first 48 hours after ICU admission. Directly prior to and after 1 hour of magnesium sulphate (MgS) infusion (2 gram) systemic hemodynamic variables, sublingual SDF images and standard laboratory tests, were obtained.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • severe sepsis and septic shock

Exclusion criteria

  • pregnancy
  • oral bleeding
  • age < 18 years
  • liver cirrhosis
  • acute arrhythmias
  • advanced malignancy or a mean arterial pressure (MAP) < 65 mmHg refractory to vasopressors

Treatment and study plan

Magnesium sulfate

Drug

2 gram in 1 hour

Primary outcomes

  1. microvascular flow index

    Time frame: 1 hour

    Directly prior to and after 1 hour of magnesium sulphate (MgS) infusion (2 gram) systemic hemodynamic variables, sublingual SDF images and standard laboratory tests, were obtained.

Sponsors and collaborators

Lead sponsor

Frisius Medisch Centrum

Other

Collaborators

  • Lithuanian University of Health Sciences

Registry information

Official study title

Microcirculatory Changes During Open Label Magnesium Sulphate Infusion in Severe Sepsis and Septic Shock

Important dates

Study start
2010
Primary completion
2010
Study completion
2011
First posted
Apr 11, 2011
Registry last updated
Apr 11, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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