Microbiota and Carcinogenesis of Small-intestine Neuroendocrine Tumors

The aim of the study is to investigate the impact of the microenvironment on tumorigenesis of small intestinal neuroendocrine tumors often located in the terminal ileum, without identified driver mutations.

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Key information

Conditions

Small-intestine Neuroendocrine Tumors Carcinogenesis Neoplasms Neoplastic Processes Pathologic Processes Pathological Conditions, Signs and Symptoms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Edouard Herriot University Hospital

Lyon, France, 69003

Location status: Recruiting

Location contact

Thomas WALTER, MD, PhD

CONTACT

[email protected]

0472117398 ext. +33

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patient with one or more small-intestine neuroendocrine tumor with indication of surgery
Patient with consent for the collection, storage and reuse of data associated with his/her disease
Age ≥ 18 years at the time of inclusion
Non-objection statement obtained for participation in the study

Exclusion criteria

Patients with poorly differentiated neuroendocrine carcinoma or NET (neuroendocrine tumors) of non-intestinal origin or mixed tumors (MiNEN)
Pregnant, parturient or breast-feeding women
Minors
Persons deprived of liberty by judicial or administrative decision
Adults under legal protection (guardianship, curatorship)

Treatment and study plan

Blood and stool sampling

Other

Blood and stool sampling

Primary outcomes

Composition of microbiota

Time frame: At day 1 and month 3

Determination of the composition of blood, fecal, intra- and peri-tumoral microbiota in patients undergoing surgery for small-intestine neuroendocrine tumor.

Study contacts

Contact information is provided by the study sponsor or research team.

Thomas WALTER, MD, PhD

CONTACT

[email protected]

0472117398 ext. +33

Sponsors and collaborators

Lead sponsor

Hospices Civils de Lyon

Other

Registry information

Acronym: Microbio-siNET

Important dates

Study start: 2024
Primary completion: 2029
Study completion: 2029
First posted: Oct 3, 2024
Registry last updated: Apr 4, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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