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NCT Number: NCT06895772

Microbial Community Characteristics in Intestinal Mucosal Tissue of Patients With CD

The characteristics of the intestinal microbiota in Crohn's disease and their relationship with disease pathogenesis have not yet been fully elucidated. Therefore, this study aims to analyze the microbial community characteristics in the intestinal mucosal tissue of Crohn's disease patients and fill this knowledge gap. Additionally, this research holds significant importance for understanding the etiology of Crohn's disease and predicting treatment outcomes.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

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Key information

Conditions

Crohn's Disease (CD)

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Qilu hospital of shandong university

Jinan, Shandong, 250012, China

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with Crohn's disease undergoing endoscopic examination
  • Healthy individuals with no symptoms undergoing colonoscopy without any lesions detected
  • Patients undergoing small intestinal endoscopy due to symptoms but with negative examination results.
  • Age between 18 and 80 years.
  • Patients or authorized family members sign the relevant informed consent forms.

Exclusion criteria

  • Patients with concurrent digestive system diseases that may affect the study results, including tumors, infections, or other autoimmune diseases.
  • Patients with concurrent non-digestive system diseases that may affect the study results, including tumors, infections, or autoimmune diseases.
  • Patients who have taken probiotics or antibiotics within the past week.
  • Patients with psychiatric disorders or other conditions that prevent them from cooperating with the study.
  • Patients participating in other clinical trials that may interfere with the results of this study.

Treatment and study plan

Primary outcomes

  1. The characteristics of the intestinal microbiota in Crohn's disease

    Time frame: 12 months

    Analyze the characteristics of the microbiota within the intestinal mucosal tissue of patients with Crohn's disease；Analyze the differences in the microbiota between the lesional and normal intestinal mucosal tissues of patients with Crohn's disease；Analyze the differences in the microbiota within the intestinal mucosal tissue of patients with Crohn's disease before and after treatment.

Secondary outcomes

  1. Contrast the characteristics of the intestinal microbiota in Crohn's disease and healthy individuals

    Time frame: 12 months

    Compare the differences in the microbiota within the intestinal mucosal tissue between patients with Crohn's disease and healthy individuals

Sponsors and collaborators

Lead sponsor

Shandong University

Other

Registry information

Official study title

Analysis of Microbial Community Characteristics in Intestinal Mucosal Tissue of Patients With Crohn's Disease

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Mar 26, 2025
Registry last updated
Mar 26, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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