Microbial Colonization and Change of Chronic Keratinized Hand Eczema After Using Halometasone Triclosan

The clinical study of the microbial colonization of chronic keratinized hand eczema and the change of microbial colonization after external using of Halometasone Triclosan Cream

Inclusion criteria

• Age ≥ 18 years
• Chronic Keratinized hand eczema for at least 3 months
• The affected area is greater than 30%
• Overall assessment of the severity of the disease(IGA)≥3 OR HEES≥13
• No obvious incentive .Who have read the instructions of the subject, agreed to and signed written informed consent, and have been able to provide a personal medical history.

Exclusion criteria

• Pregnancy, breast feeding
• Severe liver and kidney disease, blood system disease, autoimmune disease, chronic severe infection, diabetes, mental illness, drug use, alcohol abuse, etc
• Malignant neoplasms or other serious maladies that may affect the correct assessment of efficacy
• Topical corticosteroid was suspended for less than 2 weeks;The system used corticosteroids and other immunosuppressive agents (thunder vine and other drugs) which were suspended for less than four weeks
• Eczema of the facial and skin creases
• Atopic dermatitis, contact dermatitis, blister hand eczema, contact urticaria, discoid eczema
• participated in other clinical trials within 3 months.
• Known sensitivity to Halometasone Triclosan
• failure to follow the prescribed medication or the incomplete record of the test process which will affect the curative effect judgment
• Other reasons why researchers think they should not be included