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Completed

NCT Number: NCT04802889

Microarchitecture of Vitreoretinal Contact

Investigation of the vitreoretinal contact microarchitecture in the macular and paramacular zones of the human retina.

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Key information

Conditions

Vitreoretinal Detachment Vitreo-Retinal Adhesion

Age range

35 year–45 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

S.N. Fedorov Nmrc "Mntk "Eye Microsurgery"

Moscow, 127486, Russia

About this study

Purpose: to study the features of the macular ILM, to study the features of the preretinal structures of the vitreous body of the Central retinal region, morphofunctional features of preretinal hyalocytes, and the mechanism of vitreoretinal adhesion.

Study Protocol: examination of donor human eyes obtained from an eye Bank after sampling material for corneal transplantation.

Research method: scanning electron microscopy (SEM) of the central retina (macular and paramacular zone): ILM, preretinal vitreous.

Scientific hypothesis: vitreoretinal adhesion is provided not by laminin and fibronectin, but by the interweaving of vitreous collagen fibers between the epiretinal vitreous (more firmly fixed to the retinal surface) and the cortical vitreous.

Expected results: determination of ILM thickness in the macular zone, microanatomy of preretinal vitreous strutcures, and possible mechanism of vitreoretinal adhesion, establishing the possibility of intravital synthesis of collagen fibers synthesis in the adult vitreous.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • eyes from donors without concomitant multiple organ pathology and ophthalmic pathology

Exclusion criteria

  • eye injury, age over 45 years, concomitant multiple organ pathology, previous eye diseases

Treatment and study plan

scanning electron microscopy

Other

scanning electron microscopy of the сentral retina and preretinal structures

Primary outcomes

  1. the ILM thickness in the macular zone (foveola)

    Time frame: within 3 days after receiving the cadaver eyes

    the ILM thickness in the macular zone (foveola) in mkm by scanning electron microscopy data

  2. superficial microstructure of ILM

    Time frame: within 3 days after receiving the cadaver eyes

    by scanning electron microscopy data

  3. features of the structural microarchitecture of the preretinal vitreous in the macular zone

    Time frame: within 3 days after receiving the cadaver eyes

    by scanning electron microscopy data

  4. morphofunctional features of preretinal hyalocytes.

    Time frame: within 3 days after receiving the cadaver eyes

    by scanning electron microscopy data

Sponsors and collaborators

Lead sponsor

The S.N. Fyodorov Eye Microsurgery State Institution

Other Gov

Registry information

Important dates

Study start
2008
Primary completion
2020
Study completion
2020
First posted
Mar 17, 2021
Registry last updated
Mar 17, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.