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Completed

NCT Number: NCT07155018

Micro-Osteoperforations to Accelerate Maxillary Canine Retraction in Class I Malocclusion

This single-blinded, split-mouth randomized controlled trial investigates whether micro-osteoperforations (MOPs) can accelerate maxillary canine retraction in orthodontic patients requiring bilateral premolar extraction. The study also evaluates postoperative pain levels using the Visual Analog Scale at 1, 3, and 7 days.

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Key information

Conditions

Malocclusion, Angle Class I Malocclusion Stomatognathic Diseases Tooth Diseases

Age range

16 year–25 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Can Tho University Hospital

Can Tho, Vietnam

About this study

MOPs are a flapless, minimally invasive surgical technique that stimulates bone remodeling and may reduce orthodontic treatment time. In this trial, one side of each patient receives MOPs while the contralateral side serves as control. Canine retraction is performed using miniscrews, power arms, and NiTi coil springs. Outcomes include the rate of canine movement over 16 weeks and pain assessment using VAS.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 16-25 years
  • Patients requiring bilateral extraction of maxillary first premolars as part of orthodontic treatment
  • Angle Class I molar relationship
  • No previous orthodontic treatment

Exclusion criteria

  • History of craniofacial trauma or congenital anomalies
  • Systemic or bone-related diseases
  • Current smoking
  • Use of medications affecting bone metabolism

Treatment and study plan

Micro-osteoperforations (MOPs)

Procedure

Maxillary canine retraction with miniscrew anchorage and NiTi closed-coil springs, without micro-osteoperforations.

Conventional Canine Retraction

Procedure

Maxillary canine retraction with miniscrew anchorage and NiTi closed-coil springs, without micro-osteoperforations

Primary outcomes

  1. Rate of Maxillary Canine Retraction

    Time frame: Baseline, 4, 8, 12, and 16 weeks

    Distance of maxillary canine retraction measured on 3D digital dental models using intraoral scanning.

Secondary outcomes

  1. Pain Level (VAS Score)

    Time frame: Day 1, Day 3, Day 7 after intervention

    atient-reported pain intensity measured using a 10-cm Visual Analog Scale (VAS), with scores ranging from 0 (no pain) to 10 (worst pain imaginable).

Sponsors and collaborators

Lead sponsor

Can Tho University of Medicine and Pharmacy

Other

Registry information

Official study title

Effectiveness of Micro-Osteoperforations (MOPs) in Accelerating Maxillary Canine Retraction in Angle Class I Malocclusion: A Randomized Controlled Trial.

Acronym: MOPs

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Sep 4, 2025
Registry last updated
Sep 4, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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