Micro-movements in Patients With Prolonged Disorders of Consciousness

In accordance with the inclusion and exclusion criteria, a total of about 178 participants will be recruited, including about 89 confirmed cases of prolonged disorders of consciousness and 89 healthy control subjects (HCs). Utilizing the random split algorithm from the machine learning library sklearn, the dataset will be randomly divided into a training set (70%) and a testing set (30%). General information about the participants such as age, gender, time and location of injury, as well as medical history, family history, medication history, and surgical history will be collected.

Participants will undergo dual-person, multiple assessments using the CRS-R scale to evaluate auditory, visual, motor, speech responsiveness, communication, and arousal levels. Micro-movement changes in response to various emotional stimuli will be collected, along with EEG and MRI data.

Follow-up evaluations will be conducted on all enrolled patients using the CRS-R scale and the GOS scale, with a follow-up period of 6 months.

Inclusion criteria

• Patients with consciousness disorders for more than 28 days following severe brain injury, assessed by the CRS-R scale to meet the criteria for VS or MCS;
• Aged between 18 and 80 years;
• Stable vital signs;
• Voluntary participation of family members with signed informed consent;
• Good cooperation, minimal facial and spontaneous activities, no use of antiepileptic or sedative drugs.

Exclusion criteria

• Locked-in syndrome;
• Contraindications for EEG examination;
• Contraindications for MRI scanning, such as the presence of internal metallic implants;
• Diseases and factors that may affect brain function assessment, such as metabolic disorders, poisoning, shock, etc.