Skip to main content
OpenTrials
Not Yet Recruiting

NCT Number: NCT07018310

Micro Assays for HemATology Malignancies Antibody Treatment

Hematological malignancy is a disease of the blood. In some cases, this pathology requires therapeutic management, which is not necessarily the case for you. Nevertheless, to improve the management of patients who need it, we are conducting research to assess the state of your immune system. Indeed, the role of the immune system is not limited to controlling infections, but is also important in controlling the proliferation of cancer cells, in hematology as in other types of cancer. Your immune system can play a spontaneous anti-tumor control role, but some so-called "immunotherapy" treatments aim to destroy cancer cells by stimulating the immune system, restoring its capabilities, and directing the immune response against tumor cells. For this immunotherapy treatment to be effective, since it uses your own immune cells (in most cases), these cells must be in a state to respond and be able to destroy the tumor. It is this ability to activate immune cells that is tested in this research protocol, using a simple test that could in future be used in routine clinical practice. But to understand why these immune cells don't work, we will also have to carry out genetic tests to analyze the various molecules that could interfere with the immune response, and try to inhibit the molecules that prevent the immune response.

Not Yet Recruiting

Trial opening soon.

Get Notified

Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Assisitance Publique Hôpitaux de Marseille

Marseille, 13005, France

Location contact

Régis Costello Pr

CONTACT

[email protected]

0491435817 ext. 33

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male or Female over 18 years of age
  • Patient with a hematological malignancy likely to benefit from immunotherapy (in any form; at the discretion of the referring physician)
  • Before the start of 1st-line treatment, successive lines or before autograft (chemotherapy-free for at least 4 weeks in these cases).
  • Patient has received information about the study and has not expressed opposition.
  • Patient who is a beneficiary or entitled beneficiary of a social security scheme

Exclusion criteria

  • Person in a period of exclusion from another research protocol at the time the non-opposition is signed.
  • Subjects covered by articles L1121-5 to 1121-8 of the French Public Health Code, i.e. :
  • Persons deprived of their liberty by judicial or administrative decision
  • Persons subject to psychiatric monitoring under articles L3112-1 and L3113-1 who are not covered by the provisions of article L1121-8
  • Minors
  • Adults under legal protection or unable to express their consent.
  • A person who cannot read and understand the French language well enough to be able to consent to take part in research.

Treatment and study plan

Blood sampling

Other

Additional blood sampling as part of routine care

Primary outcomes

  1. Percentages of immune effectors

    Time frame: At the enrollement in the study

    Percentages of immune effectors responding to stimulation, assessed in patients with hematological malignancies

Secondary outcomes

  1. Activation percentages (cytometry) vs. polymorphism expression percentage (molecular biology)

    Time frame: At the enrollement

    Analysis and comparison of activation percentages (cytometry) vs. polymorphism expression percentage (molecular biology)

Study contacts

Contact information is provided by the study sponsor or research team.

Régis Costello Pr

CONTACT

[email protected]

0491435817 ext. 33

Sponsors and collaborators

Lead sponsor

Assistance Publique Hopitaux De Marseille

Other

Registry information

Acronym: MAHATMAt

Important dates

Study start
2026
Primary completion
2029
Study completion
2029
First posted
Jun 12, 2025
Registry last updated
Nov 20, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.