Methylation Level of SHOX2 in Endobronchial Ultrasound With Real-time Guided Transbronchial Needle Aspiration for Lung Cancer Staging

A DNA hypermethylation of the gene locus SHOX2 can be frequently found in lung cancer tissue. The purpose of this study is to determine whether the assessment of the hypermethylation level of SHOX2 in specimens obtained by endosonographic guided bronchoscopy makes a contribution to lung cancer staging.

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Key information

Conditions

Lung Cancer With Mediastinal Lymph Node Involvement Lung Diseases Lung Neoplasms Neoplasms Neoplasms by Site Respiratory Tract Diseases Respiratory Tract Neoplasms Thoracic Neoplasms

Age range

18 year–90 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Ruhrlandklinik - Universitätsklinikum Essen

Essen, 45239, Germany

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

clinical diagnosis of lung cancer
enlarged mediastinal or hilar lymph nodes (>10 mm)

Exclusion criteria

clinical condition which excludes general anesthesia

Treatment and study plan

No intervention

Other

Primary outcomes

Diagnostic Performance of SHOX2

Time frame: one Year

Diagnostic performance of SHOX2 methylation Level as biomarker for lung cancer compared to histologic evaluation of EBUS-TBNA specimen alone.

Sponsors and collaborators

Lead sponsor

University Hospital, Essen

Other

Collaborators

Epigenomics, Inc

Registry information

Important dates

Study start: 2012
Primary completion: 2012
Study completion: 2014
First posted: Jul 30, 2012
Registry last updated: Oct 26, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed