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NCT Number: NCT05991687

Methods for Effective Disposal of Surplus Analgesics to Facilitate Elimination

The primary objective is to evaluate the difference in outcomes for mail-in vs. in-home disposal methods for leftover prescription opioids after discharge from surgery.

Recruiting

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Key information

Conditions

Surgery Analgesics, Opioids

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Michigan

Ann Arbor, Michigan, 48109, United States

Location status: Recruiting

Location contact

Heather Lipkovitch

CONTACT

[email protected]

734-936-4280

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Anticipated to be prescribed and use an opioid medication to treat acute pain after elective outpatient surgery
  • Opioid-naive

Exclusion criteria

  • Inability to receive email and/or phone calls for follow up assessment

Treatment and study plan

In-home drug disposal pouch

Other

Will receive a drug disposal pouch to inactivate leftover prescription opioids for disposal after surgery.

Mail-in prepaid envelope

Other

Will receive a prepaid envelope to mail leftover prescription opioids for disposal after surgery

Primary outcomes

  1. Use of assigned disposal method

    Time frame: 2 weeks after surgery

    Among patients who have leftover opioids, patient report of the use of their assigned mail-in or in-home method of disposal by 2 weeks after surgery.

Secondary outcomes

  1. Use of safe disposal method

    Time frame: 2 weeks after surgery

    Patient-reported use of a method for disposal of leftover opioids that includes mail-in, in-home, pharmacy drop off, or flushing down the toilet by

  2. Use of any disposal method

    Time frame: 2 weeks after surgery

    Patient-reported use of any method to dispose of leftover opioids, that includes assigned methods, safe methods, and other methods such as placing in the trash

  3. Feasibility of Intervention Measure (FIM)

    Time frame: 2 weeks after surgery

  4. Acceptability of Intervention Measure (AIM)

    Time frame: 2 weeks after surgery

  5. Patient-Reported Satisfaction with Use of Disposal Method (study derived question)

    Time frame: 2 weeks after surgery

    Patient report of overall satisfaction with use of the assigned disposal method, on a 0 (worst) to 10 (best) numeric scale

Study contacts

Contact information is provided by the study sponsor or research team.

Heather Lipkovitch

CONTACT

[email protected]

734-936-4280

Sponsors and collaborators

Lead sponsor

University of Michigan

Other

Collaborators

  • Michigan Department of Health and Human Services

Registry information

Acronym: MEDSAFE

Important dates

Study start
2023
Primary completion
2026
Study completion
2026
First posted
Aug 14, 2023
Registry last updated
Mar 12, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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