Metformin Treatment, Renal Function and Lactic Acidosis

From a central registry at the National Board of Health and Welfare in Sweden collect all patients in the city of Malmö prescribed metformin during two years. Glomerular filtration rate (eGFR) was estimated from the CKD-EPI formula (n=5408) and compared to a control material (n=2815) from the same town. All cases of severe lactic acidosis rendering ICU admission were also sought. The study hypothesis is that metformin is prescribed to patients with lower GFR than anticipated with very few cases of lactic acidosis registered.

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Key information

Conditions

Type 2 Diabetes Mellitus Acid-Base Imbalance Acidosis Acidosis, Lactic Diabetes Mellitus Diabetes Mellitus, Type 2 Endocrine System Diseases Glucose Metabolism Disorders Metabolic Diseases Nutritional and Metabolic Diseases

Age range

18 year–99 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Dept of Nephrology

Malmö, SE 20502, Sweden

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients in the city of Malmö prescribed metformin at least three times during two years
Available at least one p-creatinine during the two years

Exclusion criteria

Sponsors and collaborators

Lead sponsor

Skane University Hospital

Other

Registry information

Official study title

Metformin Treatment, Renal Function and Lactic Acidosis. A Population Based

Important dates

Study start: 2011
Primary completion: 2011
Study completion: 2011
First posted: May 24, 2011
Registry last updated: Sep 10, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

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