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OpenTrials
Completed

NCT Number: NCT04597827

Metacognition in Semantic Dementia: Comparison With Alzheimer's Disease

This study aims at exploring patients' ability to monitor their own memory performance depending on their primary deficit and the type of memory involved in the criterion task. The goal is to evaluate if semantic dementia (SD) and Alzheimer's disease (AD) differently affect patients' awareness of their memory abilities.

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Key information

Conditions

Semantic Dementia Alzheimer Disease Brain Diseases Central Nervous System Diseases Dementia Frontotemporal Dementia Frontotemporal Lobar Degeneration Healthy Mental Disorders Metabolic Diseases Nervous System Diseases Neurocognitive Disorders Neurodegenerative Diseases Nutritional and Metabolic Diseases Proteostasis Deficiencies TDP-43 Proteinopathies Tauopathies

Sex eligibility

All sexes

Study type

Observational

Primary location

CHU Angers, Angers, France

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About this study

Patients who will give their informed non-opposition will be included. Participants will undergo 6 metacognitive tasks in which they will be tested on newly learnt information (i.e., episodic memory) or prior knowledge (i.e., semantic memory) and asked to evaluate their performance either prior or after the test. Correlation between their evaluation and their actual performance will be measured. Performance and correlations will be compared across groups.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • native French-speakers
  • normal or corrected-to-normal vision
  • for patients ONLY : doctor-approved diagnosis of semantic dementia or Alzheimer's disease
  • for healthy participants ONLY: score above 27 on the MMSE
  • non-opposition in participation

Exclusion criteria

  • other neurological/ psychiatric disorder, or cognitive disorder that might affect general cognition
  • drug or alcohol abuse

Treatment and study plan

Metacognition tests

Other

Test on episodic or semantic memory

Primary outcomes

  1. Metacognitive bias on the episodic predictive judgment task

    Time frame: End of study : around May 2022

    Metacognitive bias will be assessed by subtracting the mean proportion of the metacognitive judgments to the actual memory performance. Bias will range from -1 (underestimation) to 1 (overestimation).

  2. Metacognitive accuracy on the episodic predictive judgment task

    Time frame: End of study : around May 2022

    Metacognitive accuracy will be assessed by calculating a gamma correlation for each participant. Metacognition accuracy allows to evaluate people's ability to discriminate correct responses from incorrect responses. Gamma correlation range from -1 to 1.

  3. Metacognitive bias on the semantic predictive judgment task

    Time frame: End of study : around May 2022

    Metacognitive bias will be assessed by subtracting the mean proportion of the metacognitive judgments to the actual memory performance. Bias will range from -1 (underestimation) to 1 (overestimation).

  4. Metacognitive accuracy on the semantic predictive judgment task

    Time frame: End of study : around May 2022

    Metacognitive accuracy will be assessed by calculating a gamma correlation for each participant. Metacognition accuracy allows to evaluate people's ability to discriminate correct responses from incorrect responses. Gamma correlation range from -1 to 1.

  5. Metacognitive bias on episodic global judgment task

    Time frame: End of study : around May 2022

    Metacognitive bias will be assessed by subtracting the mean proportion of the metacognitive judgments to the actual memory performance. Bias will range from -1 (underestimation) to 1 (overestimation).

  6. Metacognitive bias on semantic global judgment task

    Time frame: End of study : around May 2022

    Metacognitive bias will be assessed by subtracting the mean proportion of the metacognitive judgments to the actual memory performance. Bias will range from -1 (underestimation) to 1 (overestimation).

  7. Metacognitive bias on the episodic retrospective judgment task

    Time frame: End of study : around May 2022

    Metacognitive bias will be assessed by subtracting the mean proportion of the metacognitive judgments to the actual memory performance. Bias will range from -1 (underestimation) to 1 (overestimation).

  8. Metacognitive accuracy on the episodic retrospective judgment task

    Time frame: End of study : around May 2022

    Metacognitive accuracy will be assessed by calculating a gamma correlation for each participant. Metacognition accuracy allows to evaluate people's ability to discriminate correct responses from incorrect responses. Gamma correlation range from -1 to 1.

  9. Metacognitive bias on the semantic retrospective judgment task

    Time frame: End of study : around May 2022

    Metacognitive bias will be assessed by subtracting the mean proportion of the metacognitive judgments to the actual memory performance. Bias will range from -1 (underestimation) to 1 (overestimation).

  10. Metacognitive accuracy on the semantic retrospective judgment task

    Time frame: End of study : around May 2022

    Metacognitive accuracy will be assessed by calculating a gamma correlation for each participant. Metacognition accuracy allows to evaluate people's ability to discriminate correct responses from incorrect responses. Gamma correlation range from -1 to 1.

Sponsors and collaborators

Lead sponsor

University Hospital, Grenoble

Other

Registry information

Acronym: META-DEM

Important dates

Study start
2020
Primary completion
2022
Study completion
2022
First posted
Oct 22, 2020
Registry last updated
Aug 7, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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