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Completed

NCT Number: NCT01467752

Metacarpophalangeal Joint Reconstruction Using a Vascularized Cartilage and Bone Graft

Traumatic cartilage loss of the joint is central to the development of joint failure in arthritis. The study on the use of a bone graft for reconstruction of metacarpophalangeal joint defects.

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Key information

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1

Primary location

The second hospital of Qinhuangdao

Qinhuangdao, Hebei, 066600, China

About this study

The metacarpophalangeal joint is vital for hand function. Cartilage loss of the joint is central to the development of joint failure in arthritis. Although various treatments have been proposed, the management remains a challenging problem.Previous anatomical studies have shown that, at the base of the metacarpal, there were nutrient arteries inserting into the dorsum of the metacarpal. The nutrient arteries arise from the distal and middle dorsal carpal arches that run distally to the first to fourth dorsal metacarpal arteries (DMAs. These studies prompt us to use a reverse vascularized cartilage and bone graft based on the DMA. The metacarpal consists of a widened proximal base. The joint surface to the capitate is convex anteriorly and dorsally concave, where it extends to the styloid process on the dorsolateral aspect of the metacarpal base. The unique contour stimulates our imagination and creativity to use a portion of the joint surface for reconstruction of metacarpophalangeal joint defects. The purpose of this study is to report the novel technique and to evaluate the effectiveness of the treatment.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • a cartilage defect at either proximal or distal MCP joint;
  • either an acute or old injury;
  • loss of 1/4 of joint entire surface that seen on plain radiographs, CT scan, and intraoperative finding;
  • and with or without MCP joint subluxation.

Exclusion criteria

  • large defects involved double joint surfaces;
  • the size of the defect involving less than 1/4 of the joint surface;
  • associate with infection or other diseases that restrict to use the technique.

Treatment and study plan

MCP joint

Procedure

reconstruction of metacarpophalangeal (MCP) joint using a bone graft

Other names: MCP joint reconstruction

Primary outcomes

  1. Range of motion; Arm, Shoulder and Hand questionnaire

    Time frame: 4 years

    The active motions of the hand were measured by a goniometer. The patients rated their MCP joint pain, the donor joint pain, and scar pain using a line by a visual analogue scale (VAS). We used the Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire to assess the hand function.

Secondary outcomes

  1. Pain

    Time frame: 4 years

    joint pain is assessed using visual analogue scale

Sponsors and collaborators

Lead sponsor

The Second Hospital of Qinhuangdao

Other

Registry information

Official study title

Phase 1 Study for Reconstruction of Metacarpophalangeal Joint Using a Vascularized Cartilage and Bone Graft From the Third Metacarpal

Acronym: MJRUVCBG

Important dates

Study start
2005
Primary completion
2005
Study completion
2009
First posted
Nov 9, 2011
Registry last updated
Nov 9, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.