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OpenTrials
Completed

NCT Number: NCT01922323

Metabolomics of Liver Regeneration Following Partial Hepatectomy in Healthy Living Liver Donors

The PI will study metabolism during liver regeneration in living liver donors

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Key information

Conditions

Liver Insufficiency Digestive System Diseases Hepatic Insufficiency Liver Diseases

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Baylor University Medical Center

Dallas, Texas, 75246, United States

About this study

Samples of blood and urine will be collected from study participants at defined timepoints. The samples will be evaluated to study the metabolism of the regenerating liver after a portion of the liver has been donated from a living donor.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Potential donor must be in excellent medical and psychological health.
  • Potential donor must be between the ages of 18 and 60.
  • Must have a compatible blood type to the recipient.
  • Must have health care coverage for non-donor related health issues that arise post donation
  • Recipient and donor must have compatible body size.
  • Donors Body Mass Index (BMI) must be less than 30.
  • All previous donor abdominal surgeries will be reviewed on a case by case basis by the surgeon.

Exclusion criteria

  • Positive blood test for Human Immunodeficiency Virus, Hepatitis C virus, Hepatitis B virus
  • The size of the donor liver is not large enough to safely resection and still retain enough volume to function normally after the surgery.
  • Liver biopsy show liver cirrhosis or early stages of HCC.

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Treatment and study plan

Primary outcomes

  1. Characterized Metabolic Changes during liver regeneration

    Time frame: one year after donation

Sponsors and collaborators

Lead sponsor

Baylor Research Institute

Other

Registry information

Important dates

Study start
2013
Primary completion
2016
Study completion
2016
First posted
Aug 14, 2013
Registry last updated
Mar 28, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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